Сибирский федеральный университет

Тип публикации: статья из журнала

Год издания: 2022

Идентификатор DOI: 10.3390/pharmaceutics14122678

Ключевые слова: galactomannan sulfate, galactoglucomannan sulfate, chromogenic substrate, thrombin, factor Xa, platelet aggregation

Аннотация: Polysaccharides are important structural components of all plant species. Gel-like polysaccharides have found wide application in various fields, including medicine, construction, and the food industry. In the present work, galactomannan and galactoglucomannan gel-like polysaccharides were modified with sulfate groups and their anticoagulant activity was studied. Sulfation with chlorosulfonic acid in pyridine and with sulfamic acid in pyridine and a sulfamic acid–urea deep eutectic solvent were used as synthesis routes. The resulting gel-like polysaccharide sulfates were studied by elemental analysis, Fourier-transform infrared spectroscopy, and gel permeation chromatography. It was established that the anticoagulant effect of sulfated galactoglucomannan (SGGM) and galactomannan (SGM-1 and SGM-2) is related to an independent antithrombin-independent decrease in the amidolytic activity of thrombin and factor Xa. It is shown that the inhibitory activity of SGGM and SGM-2 against the collagen-induced platelet aggregation can be an additional factor in selecting compounds that are most promising for modifying polymer surfaces to ensure resistance to blood clotting.

Журнал: Pharmaceutics

Выпуск журнала: Т.14, №12

Номера страниц: 2678

ISSN журнала: 19994923

• Drozd N.N. (National Medical Research Center of Hematology, Ministry of Health of the Russian Federation)
• Kuznetsova S.A. (Institute of Chemistry and Chemical Technology, Krasnoyarsk Science Center, Siberian Branch, Russian Academy of Sciences)
• Malyar Y.N. (School of Non-Ferrous Metals and Materials Science, Siberian Federal University)
• Kazachenko A.S. (?Department of Biological Chemistry with Courses in Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University, Ministry of Healthcare of the Russian Federation)
• Borovkova V.S. (School of Non-Ferrous Metals and Materials Science, Siberian Federal University)
• Berezhnaya Y.D. (Institute of Chemistry and Chemical Technology, Krasnoyarsk Science Center, Siberian Branch, Russian Academy of Sciences)

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