Тип публикации: статья из журнала
Год издания: 2021
Идентификатор DOI: 10.1016/j.apsusc.2021.149334
Ключевые слова: corticosteroids, delivery system, detonation nanodiamonds, modification, prolonged release
Аннотация: The application of detonation nanodiamonds (DNDs) in delivery systems has been demonstrated many times for a variety of substances, including anti-inflammatory drugs, antibiotics, antineoplastic agents, vitamins etc. The applicability of detonation nanodiamonds as a carrier for delivery of corticosteroids is investigated in this study. Commercial DNDs were modified to obtain particles with high colloidal stability in aqueous suspensions. Physical adsorption was then used to conjugate the DNDs with methylprednisolone sodium succinate and dexamethasone sodium phosphate. The experimental adsorption isotherms were fit with Langmuir and Freundlich adsorption models. The results of in vitro release study demonstrated an explicit prolonged effect of DNDs, due to which a sustained release of the adsorbed drugs was provided.
Издание
Журнал: Applied Surface Science
Выпуск журнала: Т. 551
Номера страниц: 149334
ISSN журнала: 01694332
Издатель: Elsevier Science Publishing Company, Inc.
Персоны
- Kyu Rhee C. (Korea Atomic Energy Research Institute)
- Burov A.E. (Institute of Biophysics SB RAS,Federal Research Center “Krasnoyarsk Science Center SB RAS”)
- Puzyr A.P. (Institute of Biophysics SB RAS,Federal Research Center “Krasnoyarsk Science Center SB RAS”)
- Bondar V.S. (Institute of Biophysics SB RAS,Federal Research Center “Krasnoyarsk Science Center SB RAS”)
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