Тип публикации: статья из журнала
Год издания: 2014
Идентификатор DOI: 10.1080/09205063.2013.862400
Ключевые слова: electrospinning, polyhydroxyalkanoates, ultrafine fibers, physical-mechanical properties, fibroblast cells, Electrospinning, Fibroblast cells, Physicalmechanical properties, Polyhydroxyalkanoates, Ultrafine fibers, Electrospinning parameters, Fibroblast cells, Physical-mechanical properties, Polyhydroxyalkanoates, Polymer concentrations, Structure and properties, Tissue engineering applications, Ultra-fine fibers, Cell culture, Fibers, Fibroblasts, Polymers, Scaffolds (biology), Electrospinning, molecular scaffold, monomer, polyhydroxyalkanoic acid, animal cell, article, cell adhesion, cell growth, cell viability, chemical composition, chemical structure, electrospinning, fibroblast, molecular mechanics, mouse, nonhuman, priority journal, surface property, tissue engineering, Animals, Biocompatible Materials, Cell Adhesion, Cell Survival, Fibroblasts, Materials Testing, Mechanical Phenomena, Mice, Microscopy, Electron, Scanning, NIH 3T3 Cells, Polyhydroxyalkanoates, Polymers, Solutions, Tissue Engineering, Tissue Scaffolds
Аннотация: In this study, electrospinning was used to prepare ultrafine fibers from PHAs with different chemical compositions: P(3HB) and copolymers: P(3HB-co-4HB), P(3HB-co-3HV), and P(3HB-co-3HHx). The main process parameters that influence ultrafine fiber diameter and properties (polymer concentration, solution feeding rate, working distance, and applied voltage) have been investigated and their effects evaluated. The study revealed electrospinning parameters for the production of high-quality ultrafine fibers and determined which parameters should be varied to tailor the properties of the products. This study is the first to compare biological and physical-mechanical parameters of PHAs with different chemical compositions as dependent upon the fractions of monomers constituting the polymers and ultrafine fiber orientation. Mechanical strength of aligned ultrafine fibers prepared from different PHAs is higher than that of randomly oriented ones; no significant effect of ultrafine fiber orientation on surface properties has been found. None of the fibrous scaffolds produced by electrospinning from PHAs had any adverse effects on attachment, growth, and viability of NIH 3T3 mouse fibroblast cells, and all of them were found to be suitable for tissue engineering applications.
Журнал: JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Выпуск журнала: Vol. 25, Is. 4
Номера страниц: 370-393
ISSN журнала: 09205063
Место издания: ABINGDON
Издатель: TAYLOR & FRANCIS LTD
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