Сибирский федеральный университет

Тип публикации: статья из журнала

Год издания: 2021

Идентификатор DOI: 10.3390/nano11061459

Ключевые слова: nanodiscs, microdiscs, magnetomechanical therapy, magnetic field, the nanoscalpel

Аннотация: Magnetomechanical therapy is one of the most perspective directions in tumor microsurgery. According to the analysis of recent publications, it can be concluded that a nanoscalpel could become an instrument sufficient for cancer microsurgery. It should possess the following properties: (1) nano- or microsized; (2) affinity and specificity to the targets on tumor cells; (3) remote control. This nano- or microscalpel should include at least two components: (1) a physical nanostructure (particle, disc, plates) with the ability to transform the magnetic moment to mechanical torque; (2) a ligand—a molecule (antibody, aptamer, etc.) allowing the scalpel precisely target tumor cells. Literature analysis revealed that the most suitable nanoscalpel structures are anisotropic, magnetic micro- or nanodiscs with high-saturation magnetization and the absence of remanence, facilitating scalpel remote control via the magnetic field. Additionally, anisotropy enhances the transmigration of the discs to the tumor. To date, four types of magnetic microdiscs have been used for tumor destruction: synthetic antiferromagnetic P-SAF (perpendicular) and SAF (in-plane), vortex Py, and three-layer non-magnetic–ferromagnet–non-magnetic systems with flat quasi-dipole magnetic structures. In the current review, we discuss the biological effects of magnetic discs, the mechanisms of action, and the toxicity in alternating or rotating magnetic fields in vitro and in vivo. Based on the experimental data presented in the literature, we conclude that the targeted and remotely controlled magnetic field nanoscalpel is an effective and safe instrument for cancer therapy or theranostics.

Журнал: Nanomaterials

Выпуск журнала: Т. 11, № 6

Номера страниц: 1459

ISSN журнала: 20794991

Издатель: MDPI AG

• Zamay Tatiana N. (Krasnoyarsk State Med Univ, Lab Biomol & Med Technol, Krasnoyarsk 660029, Russia; Russian Acad Sci, Fed Res Ctr, Lab Digital Controlled Drugs & Theranost, Siberian Branch,Krasnoyarsk Sci Ctr, Krasnoyarsk 660036, Russia)
• Prokopenko Vladimir S. (Astafiev Krasnoyarsk State Pedag Univ, Inst Phys & Informat, Krasnoyarsk 660049, Russia)
• Zamay Sergey S. (Russian Acad Sci, Fed Res Ctr, Mol Elect Dept, Krasnoyarsk Sci Ctr,Siberian Branch, Krasnoyarsk 660036, Russia)
• Lukyanenko Kirill A. (Krasnoyarsk State Med Univ, Lab Biomol & Med Technol, Krasnoyarsk 660029, Russia; Russian Acad Sci, Fed Res Ctr, Lab Digital Controlled Drugs & Theranost, Siberian Branch,Krasnoyarsk Sci Ctr, Krasnoyarsk 660036, Russia; Siberian Fed Univ, Sch Fundamental Biol & Biotechnol, 79 Svobodny Pr, Krasnoyarsk 660041, Russia)
• Kolovskaya Olga S. (Krasnoyarsk State Med Univ, Lab Biomol & Med Technol, Krasnoyarsk 660029, Russia; Russian Acad Sci, Fed Res Ctr, Lab Digital Controlled Drugs & Theranost, Siberian Branch,Krasnoyarsk Sci Ctr, Krasnoyarsk 660036, Russia)
• Orlov Vitaly A. (Siberian Fed Univ, Sch Engn Phys & Radio Elect, 79 Svobodny Pr, Krasnoyarsk 660041, Russia; Russian Acad Sci, Kirensky Inst Phys Fed Res Ctr KSC, Siberian Branch, Akad Gorodok 50,Bld 38, Krasnoyarsk 660036, Russia)
• Zamay Galina S. (Krasnoyarsk State Med Univ, Lab Biomol & Med Technol, Krasnoyarsk 660029, Russia; Russian Acad Sci, Fed Res Ctr, Lab Digital Controlled Drugs & Theranost, Siberian Branch,Krasnoyarsk Sci Ctr, Krasnoyarsk 660036, Russia)
• Galeev Rinat G. (JSC NPP Radiosviaz, Krasnoyarsk 660021, Russia)
• Narodov Andrey A. (Krasnoyarsk State Med Univ, Traumatol Orthoped & Neurosurg Dept, Krasnoyarsk 660029, Russia)
• Kichkailo Anna S. (Krasnoyarsk State Med Univ, Lab Biomol & Med Technol, Krasnoyarsk 660029, Russia; Russian Acad Sci, Fed Res Ctr, Lab Digital Controlled Drugs & Theranost, Siberian Branch,Krasnoyarsk Sci Ctr, Krasnoyarsk 660036, Russia)

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