Тип публикации: статья из журнала
Год издания: 2022
Идентификатор DOI: 10.1155/2022/6353909
Аннотация: In this work, delivery systems in the form of microparticles and films containing 1,2,4-trioxolane (ozonide, OZ) based on polyhydroxyalkanoates (PHAs) were developed. Main systems' characteristics were investigated: the particle yield, average diameter, zeta potential, surface morphology, loading capacity, and drug release profile of microparticles, as well as surface morphology and release profiles of OZ-containing films. PHA-based OZ-loaded microparticles have been found to have satisfactory size, zeta potential, and ozonide loading-release behavior. It was noted that OZ content influenced the surface morphology of obtained systems. In this work, delivery systems in the form of microparticles and films containing 1,2,4-trioxolane (ozonide, OZ) based on polyhydroxyalkanoates (PHAs) were developed. Main systems' characteristics were investigated: the particle yield, average diameter, zeta potential, surface morphology, loading capacity, and drug release profile of microparticles, as well as surface morphology and release profiles of OZ-containing films. PHA-based OZ-loaded microparticles have been found to have satisfactory size, zeta potential, and ozonide loading-release behavior. It was noted that OZ content influenced the surface morphology of obtained systems. © 2022 Sergei Y. Lipaikin et al.
Издание
Журнал: ADVANCES IN POLYMER TECHNOLOGY
Выпуск журнала: Vol. 2022
Номера страниц: 6353909
ISSN журнала: 07306679
Место издания: LONDON
Издатель: WILEY-HINDAWI
Персоны
- Lipaikin Sergei Y. (Siberian Federal University, 79 Svobodnyi Av, Krasnoyarsk 660041, Russia)
- Yaremenko Ivan A. (Russian Acad Sci, ND Zelinsky Inst Organ Chem, 47 Leninsky Prosp, Moscow 119991, Russia)
- Terent'ev Alexander O. (Russian Acad Sci, ND Zelinsky Inst Organ Chem, 47 Leninsky Prosp, Moscow 119991, Russia)
- Volova Tatiana G. (Siberian Fed Univ, 79 Svobodnyi Av, Krasnoyarsk 660041, Russia; Inst Biophys SB RAS, 50-50 Akademgorodok, Krasnoyarsk 660036, Russia)
- Shishatskaya Ekaterina (Siberian Fed Univ, 79 Svobodnyi Av, Krasnoyarsk 660041, Russia)
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