Сибирский федеральный университет

Тип публикации: статья из журнала

Год издания: 2022

Идентификатор DOI: 10.20333/25000136-2022-5-107

Ключевые слова: aptamers, arabinogalactan, cancer, cisplatin, targeted delivery

Аннотация: The effectiveness of targeted delivery of cisplatin conjugate with arabinogalactan to ascitic Ehrlich carcinoma in vivo using the target ligand, the AS42 aptamer, was studied in this work. Studies conducted on male ICR mice with ascitic Ehrlich carcinoma. Antitumor therapy was carried out with cisplatin and an arabinogalactan-platinum complex (AG-Pt) and an AG-Pt complex modified with aptamers to ascitic Ehrlich carcinoma cells. The toxicity of drugs was determined on the basis of biochemical parameters of blood in healthy mice after 5-fold administration. In our studies, cisplatin treatment of Ehrlich's ascitic carcinoma for 2 weeks led to the death of 6 out of 10 animals. The toxicity of the AG-Pt complex and the AG-Pt complex modified with the aptamer was not revealed. The number of tumor cells during therapy with cisplatin conjugates decreased by 10 times compared with the control. А new promising antitumor drug based on the standard drug cisplatin, which is more effective and less toxic, was presented in the work. © 2022, Krasnoyarsk State Medical University. All rights reserved.

Журнал: Siberian Medical Review

Выпуск журнала: Vol. 2022, Is. 5

Номера страниц: 107

ISSN журнала: 18199496

Издатель: Krasnoyarsk State Medical University

• Starkov A.K. (Institute of Chemistry and Chemical Technology of the Siberian Branch of the Russian Academy of Sciences, 50, Akademgorodok, Krasnoyarsk, 660036, Russian Federation)
• Titova N.M. (Siberian Federal University, Svobodny Ave., 82A, Krasnoyarsk, 660041, Russian Federation)

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