miR-204-5p and miR-3065-5p exert antitumor effects on melanoma cells : научное издание

Тип публикации: статья из журнала

Год издания: 2018

Идентификатор DOI: 10.3892/ol.2018.8443

Ключевые слова: cell migration, cell proliferation, melanoma, microRNA-204-5p, microRNA-3065-5p

Аннотация: MicroRNA (miR)-204-5p was previously identified to be downregulated in melanoma compared with melanocytic nevi. This observation prompted a functional study on miR-204-5p and the newly-identified miR-3065-5p, two miRNAs suggested to be tumor-suppressive oncomiRs. Application of miR-204-5p mimics or inhibitors resulted in a decrease or increase, respectively, in melanoma cell proliferation and colony formation. miR-204-5p mimics hindered invasion, whereas miR-204-5p inhibitors stimulated cancer cell migration. Modulation of miR-3065-5p led to a decrease in melanoma cell proliferation, altered cell cycle distribution and increased expression levels of its target genes HIPK1 and ITGA1, possibly due to functional modifications identified in these cells. miR-204-5p and miR-3065-5p demonstrated antitumor capacities that may need to be taken into account in the development of melanoma treatment approaches.

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Издание

Журнал: Oncology Letters

Выпуск журнала: Т. 15, 6

Номера страниц: 8269-8280

ISSN журнала: 17921074

Авторы

  • Palkina N. (Department of Pathophysiology,Krasnoyarsk State Medical University)
  • Komina A. (Department of Pathophysiology,Krasnoyarsk State Medical University)
  • Aksenenko M. (Department of Pathophysiology,Krasnoyarsk State Medical University)
  • Ruksha T. (Department of Pathophysiology,Krasnoyarsk State Medical University)
  • Moshev A. (Laboratory of Cell Molecular Physiology and Pathology,Federal Research Center,Krasnoyarsk Science Center of The Siberian Branch of The Russian Academy of Sciences)
  • Savchenko A. (Laboratory of Cell Molecular Physiology and Pathology,Federal Research Center,Krasnoyarsk Science Center of The Siberian Branch of The Russian Academy of Sciences)

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