Сибирский федеральный университет

Тип публикации: статья из журнала

Год издания: 2022

Идентификатор DOI: 10.1186/s12951-022-01627-y

Ключевые слова: black body, nanozyme, plasmonic, theranostics, tumor microenvironment

Аннотация: Nanozymes are promising for precise cancer treatment, but are typically limited in terms of the low catalytic efficiency and the complexity in tumor microenvironment (TME). Herein, we describe a bimodal type of AgPd plasmonic blackbody (AgPd PB) nanozyme of compact sizes (< 30 nm), which presents not only boosted enzyme efficacy but also efficient photothermal therapy (PTT) for synergized therapy through tissue-penetrating light in the second biological window (1000–1700 nm). The synthesized hyperbranched AgPd PB nanozymes possess intense and broadband localized surface plasmonic resonance absorption of 400–1300 nm, entailing prominent photothermal efficiency (η = 45.1% at 1064 nm) for PTT. Importantly, PTT was found to significantly boost the nanozyme efficacy of both catalase (CAT) and peroxidase (POD) processes, which correspondingly decompose H2O2 to into O2 to relieve tumor hypoxia, and activate H2O2 to generate oxidative •OH radical. While the generated •OH was found to be able to minimize heat shock proteins (HSPs), which plays a vital role to counterbalance PTT effect both in vitro and in vivo. As compared to control ground without treatment, the synergized nanozyme and PTT activities resulted in about 7-fold reduction of tumor volume, thus elevating the survival rate from 0 to 80% at 30 days posttreatment. Besides the synergistic therapy, the AgPd PB nanozyme were shown to own fluorescence, computed tomography (CT), and photoacoustic (PA) imaging abilities, thus having implications for uses in imaging-guided precise cancer therapy. This study provides a paradigm of TME responsive theranostics under NIR-II light irradiation. Graphical Abstract: [Figure not available: see fulltext.] © 2022, The Author(s).

Журнал: Journal of Nanobiotechnology

Выпуск журнала: Vol. 20, Is. 1

Номера страниц: 424

ISSN журнала: 14773155

Издатель: BioMed Central Ltd

• Jia T. (MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering & State Key Laboratory of Urban Water Resource and Environment & Key Laboratory of Micro-systems and Micro-tructures Ministry of Education, Harbin Institute of Technology, Harbin, 150001, China)
• Li D. (MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering & State Key Laboratory of Urban Water Resource and Environment & Key Laboratory of Micro-systems and Micro-tructures Ministry of Education, Harbin Institute of Technology, Harbin, 150001, China)
• Du J. (MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering & State Key Laboratory of Urban Water Resource and Environment & Key Laboratory of Micro-systems and Micro-tructures Ministry of Education, Harbin Institute of Technology, Harbin, 150001, China)
• Fang X. (MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering & State Key Laboratory of Urban Water Resource and Environment & Key Laboratory of Micro-systems and Micro-tructures Ministry of Education, Harbin Institute of Technology, Harbin, 150001, China)
• Gerasimov V. (International Research Center of Spectroscopy and Quantum Chemistry, Siberian Federal University, Krasnoyarsk, 660041, Russian Federation, Institute of Computational Modelling, Federal Research Center KSC SB RAS, Krasnoyarsk, 660036, Russian Federation)
• Ågren H. (MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering & State Key Laboratory of Urban Water Resource and Environment & Key Laboratory of Micro-systems and Micro-tructures Ministry of Education, Harbin Institute of Technology, Harbin, 150001, China)
• Chen G. (MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering & State Key Laboratory of Urban Water Resource and Environment & Key Laboratory of Micro-systems and Micro-tructures Ministry of Education, Harbin Institute of Technology, Harbin, 150001, China)

• Scopus