Тип публикации: статья из журнала
Год издания: 2017
Идентификатор DOI: 10.1007/s10517-017-3924-6
Ключевые слова: alkoxyamines, phagocytic activity of peritoneal macrophages, toxicity, transplanted tumor strains, tumor cell lines
Аннотация: Effect of alkoxyamines on normal and tumor cells was studied in vitro and in vivo. In vitro experiments showed that alkoxyamines produce a dose-dependent toxic effect on cells of human breast tumor MCF7 line. Transplantation of Krebs-2 ascites carcinoma cells preincubated with alkoxyamines to mice did not induce tumor growth. An opposite effect was observed in normal mouse cells: functional activity of peritoneal macrophages increased. The possibility of using alkoxyamines as theranostic agents is discussed. © 2017, Springer Science+Business Media, LLC, part of Springer Nature.
Издание
Журнал: Bulletin of Experimental Biology and Medicine
Выпуск журнала: Vol. 164, Is. 1
Номера страниц: 49-53
ISSN журнала: 00074888
Издатель: Springer New York LLC
Персоны
- Popova N.A. (Federal Research Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russian Federation)
- Sysoeva G.M. (Institute of Medical Biotechnology, Vektor State Research Center of Virology and Biotechnology, Koltsovo, Novosibirsk Region, Russian Federation)
- Nikolin V.P. (Federal Research Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russian Federation)
- Kaledin V.I. (Federal Research Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russian Federation)
- Tretyakov E.V. (N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russian Federation)
- Edeeva M.V. (N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russian Federation)
- Balakhnin S.M. (Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russian Federation)
- Lushnikova E.L. (Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russian Federation)
- Audran G. (Aix Marseille University, Provence, France)
- Mark S. (N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russian Federation)
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