The Relationship Between the Pro-Oxidant and Antioxidant System Status of Patients with Multiple Myeloma and the Disease Stage | Научно-инновационный портал СФУ

The Relationship Between the Pro-Oxidant and Antioxidant System Status of Patients with Multiple Myeloma and the Disease Stage

Тип публикации: статья из журнала

Год издания: 2014

Идентификатор DOI: 10.1007/s10517-014-2570-5

Ключевые слова: multiple myeloma, malonic dialdehyde, antioxidant enzymes, antioxidant, catalase, ceruloplasmin, glutathione, glutathione peroxidase, glutathione transferase, hemoglobin, oxidizing agent, superoxide dismutase, malonaldehyde, adult, aged, article, clinical article, disease association, disease severity, enzyme activity, enzyme blood level, erythrocyte, erythrocyte level, female, human, human cell, human tissue, male, oxidation, blood, case control study, lipid peroxidation, metabolism, middle aged, oxidative stress, Antioxidants, Case-Control Studies, Humans, Malondialdehyde, Oxidants

Аннотация: Disturbances of the erythrocyte antioxidant system presented by LPO intensifi cation were detected in patients with multiple myeloma. Plasma concentrations of MDA in these patients were close to normal due to effective work of the nonenzymatic antioxidant system. Activities of antioxidant enzymes in the plasma were reduced, while catalase activity was high, and ceruloplasmin content did not differ from the control, this indicating suppression of the enzymatic component of the antioxidant system. In erythrocytes, the level of reduced glutathione was low, especially at stage III of the disease. Changes in SOD and catalase activities were similar to those in the plasma, while activities of glutathione-dependent enzymes were comparable to those in normal human erythrocytes.

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Издание

Журнал: BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Выпуск журнала: Vol. 157, Is. 3

Номера страниц: 375-379

ISSN журнала: 00074888

Место издания: NEW YORK

Издатель: SPRINGER

Авторы

  • Smirnova O.V. (Research Institute of Medical Problems of the North, Siberian Division of the Russian Academy of Medical Sciences)
  • Elmanova N.G. (Research Institute of Medical Problems of the North, Siberian Division of the Russian Academy of Medical Sciences)
  • Titova N.M. (Siberian Federal University)

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