Сибирский федеральный университет

Тип публикации: статья из журнала

Год издания: 2023

Идентификатор DOI: 10.3390/ijms24010410

Ключевые слова: low-dose, radionuclides, radiotoxicity, radiation hormesis, bioassay, luminous bacteria, enzymes, radioprotection, humic substances

Аннотация: Radioactive contaminants create problems all over world, involving marine ecosystems,with their ecological importance increasing in the future. The review focuses on bioeffects of a series of alpha and beta emitting radioisotopes (americium-241, uranium-(235 + 238), thorium-232, and tritium) and gamma radiation. Low-intensity exposures are under special consideration. Great attention has been paid to luminous marine bacteria as representatives of marine microorganisms and a conventional bioassay system. This bioassay uses bacterial bioluminescence intensity as the main testing physiological parameter; currently, it is widely applied due to its simplicity and sensitivity. Dependences of the bacterial luminescence response on the exposure time and irradiation intensity were reviewed, and applicability of hormetic or threshold models was discussed. A number of aspects of molecular intracellular processes under exposure to low-intensity radiation were analyzed: (a) changes in the rates of enzymatic processes in bacteria with the bioluminescent system of coupled enzymatic reactions of NADH:FMN-oxidoreductase and bacterial luciferase taken as an example; (b) consumption of an intracellular reducer, NADH; (c) active role of reactive oxygen species; (d) re- pairing of the DNA damage. The results presented confirm the function of humic substances as natural radioprotectors.

Журнал: International Journal of Molecular Sciences

Выпуск журнала: Т.24, №1

Номера страниц: 410

ISSN журнала: 14220067

Место издания: Basel

Издатель: Molecular Diversity Preservation International?

• Kolesnik Olga V. (Federal Research Center ‘Krasnoyarsk Science Center SB RAS)
• Rozhko Tatiana V. (Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University)
• Kudryasheva Nadezhda S. (Federal Research Center ‘Krasnoyarsk Science Center SB RAS)

• Ядро РИНЦ (eLIBRARY.RU)