Сибирский федеральный университет

Тип публикации: статья из журнала

Год издания: 2021

Идентификатор DOI: 10.3390/ijms22094661

Ключевые слова: Alzheimer’s disease, In vitro blood-brain barrier model, In vitro neurovascular unit model, mitochondria, neurodegeneration

Аннотация: Pathophysiology of chronic neurodegeneration is mainly based on complex mechanisms related to aberrant signal transduction, excitation/inhibition imbalance, excitotoxicity, synaptic dysfunction, oxidative stress, proteotoxicity and protein misfolding, local insulin resistance and metabolic dysfunction, excessive cell death, development of glia-supported neuroinflammation, and failure of neurogenesis. These mechanisms tightly associate with dramatic alterations in the structure and activity of the neurovascular unit (NVU) and the blood–brain barrier (BBB). NVU is an ensemble of brain cells (brain microvessel endothelial cells (BMECs), astrocytes, pericytes, neurons, and microglia) serving for the adjustment of cell-to-cell interactions, metabolic coupling, local microcirculation, and neuronal excitability to the actual needs of the brain. The part of the NVU known as a BBB controls selective access of endogenous and exogenous molecules to the brain tissue and efflux of metabolites to the blood, thereby providing maintenance of brain chemical homeostasis critical for efficient signal transduction and brain plasticity. In Alzheimer’s disease, mitochondria are the target organelles for amyloid-induced neurodegeneration and alterations in NVU metabolic coupling or BBB breakdown. In this review we discuss understandings on mitochondria-driven NVU and BBB dysfunction, and how it might be studied in current and prospective NVU/BBB in vitro models for finding new approaches for the efficient pharmacotherapy of Alzheimer’s disease.

Журнал: International Journal of Molecular Sciences

Выпуск журнала: Т. 22, № 9

ISSN журнала: 14220067

Издатель: Molecular Diversity Preservation International

• Salmina A.B. (Research Center of Neurology)
• Kharitonova E.V. (Research Institute of Molecular Medicine and Pathobiochemistry,Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University)
• Gorina Y.V. (Research Institute of Molecular Medicine and Pathobiochemistry,Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University)
• Teplyashina E.A. (Research Institute of Molecular Medicine and Pathobiochemistry,Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University)
• Malinovskaya N.A. (Research Institute of Molecular Medicine and Pathobiochemistry,Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University)
• Khilazheva E.D. (Research Institute of Molecular Medicine and Pathobiochemistry,Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University)
• Mosyagina A.I. (Research Institute of Molecular Medicine and Pathobiochemistry,Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University)
• Morgun A.V. (Research Institute of Molecular Medicine and Pathobiochemistry,Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University)
• Shuvaev A.N. (Research Institute of Molecular Medicine and Pathobiochemistry,Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University)
• Salmin V.V. (Research Institute of Molecular Medicine and Pathobiochemistry,Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University)
• Lopatina O.L. (Research Institute of Molecular Medicine and Pathobiochemistry,Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University)
• Komleva Y.K. (Research Institute of Molecular Medicine and Pathobiochemistry,Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University)

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