Сибирский федеральный университет

Тип публикации: препринт

Год издания: 2018

Ключевые слова: loud music, sound, stress, blood-brain barrier, endothelial permeability, drug brain delivery, liposomes, molecular mechanisms.

Аннотация: The blood-brain barrier (BBB) poses a significant challenge for drug brain delivery. The limitation of our knowledge about the nature of BBB explains the slow progress in the therapy of brain diseases and absence of methods for drug brain delivery in the clinical practice.Here we show that BBB opens for low/high weight molecules and nanocarriers after exposure of loud music/sound of 90 dB and 100 dB (regardless its frequency) as being easily produced by MP3/MP4 players, kitchen appliances, loudspeakers at concerts. The role of sound, sound-induced stress and molecular mechanisms behind is discussed in the framework of BBB opening as an informative platform for a novel fundamental knowledge about the nature of BBB and for the development of a non-invasive brain drug delivery technology. Social aspects of music/sound-induced opening of BBB provide completely new information about noise and healthy life conditions that will stimulate new research in this field.

Номера страниц: 509042

Место издания: https://www.biorxiv.org/content/10.1101/509042v1

• Semyachkina-glushkovskaya O.V. (Saratov State University, Department of Human and Animal Physiology, Astrakhanskaya Str. 83, Saratov 410012, Russian Federation, Russian Federation, Saratov)
• Chekhonin V.P. (Russian National Research Medical University, Department of Medical Biology, Ostrovityanova Str.1, Moscow 117997, Russian Federation)
• Bragin D.E. (University of New Mexico School of Medicine, Department of Neurosurgery, Albuquerque, NM 87131, США)
• Bragina O.A. (University of New Mexico School of Medicine, Department of Neurosurgery, Albuquerque, NM 87131, США)
• Vodovozova E.L. (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya Str. 16/10, Moscow 117997, Russian Federation, Moscow)
• Alekseeva A.S. (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya Str. 16/10, Moscow 117997, Russian Federation, Moscow)
• Salmin V.V. (Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Russia, 1, P. Zeleznyak street, Krasnoyarsk, 660022)
• Morgun A.V. (Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Russia, 1, P. Zeleznyak street, Krasnoyarsk, 660022)
• Malinovskaya N.A. (Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Russia, 1, P. Zeleznyak street, Krasnoyarsk, 660022)
• Osipova E.D. (Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Russia, 1, P. Zeleznyak street, Krasnoyarsk, 660022)
• Boitsova E.B. (Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Russia, 1, P. Zeleznyak street, Krasnoyarsk, 660022)
• Tohidpour A.A. (Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Russia, 1, P. Zeleznyak street, Krasnoyarsk, 660022)
• Shirokov A.A. (Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences , Entuziastov Ave. 13, Saratov 410049, Russian Federation)
• Navolokin N.A. (Saratov State Medical University, Department of Pathological Anatomy, Bolshaya Kazachaya Str. 112, Saratov 410012, Russian Federation)
• Yang Y. (University of New Mexico, College of Pharmac, США, Albuquerque, NM 87131, USA.)
• Zhang C. (MoE Key Laboratory for Biomedical Photonics, Collaborative Innovation Center for Biomedical Engineering, School of Engineering Sciences, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China)
• Feng W. (MoE Key Laboratory for Biomedical Photonics, Collaborative Innovation Center for Biomedical Engineering, School of Engineering Sciences, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China)
• Ulanova M.V. (Saratov State University, Department of Human and Animal Physiology, Astrakhanskaya Str. 83, Saratov 410012, Russian Federation, Russian Federation, Saratov)
• Shushunova N.A. (Saratov State University, Department of Human and Animal Physiology, Astrakhanskaya Str. 83, Saratov 410012, Russian Federation, Russian Federation, Saratov)
• Khorovodov A.P. (Saratov State University, Department of Human and Animal Physiology, Astrakhanskaya Str. 83, Saratov 410012, Russian Federation, Russian Federation, Saratov)
• Terskov A.V. (Saratov State University, Department of Human and Animal Physiology, Astrakhanskaya Str. 83, Saratov 410012, Russian Federation, Russian Federation, Saratov)
• Pavlov A.V. (Yuri Gagarin State Technical University of Saratov, 77 Politechnicheskaya Str., 410054 Saratov, Russian Federation)
• Luo Q. (MoE Key Laboratory for Biomedical Photonics, Collaborative Innovation Center for Biomedical Engineering, School of Engineering Sciences, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China)
• Zhu D. (MoE Key Laboratory for Biomedical Photonics, Collaborative Innovation Center for Biomedical Engineering, School of Engineering Sciences, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China)
• Tuchin V.V. (Institute of Precision Mechanics and Control of RAS, Laboratory of Laser Diagnostics of Technical and Living Systems, 24 Rabochaya str., Saratov 410028, Russian Federation)
• Kurths J.J. (Potsdam Institute for Climate Impact Research, Telegrafenberg A31, Potsdam, Germany)

• РИНЦ (eLIBRARY.RU)