Тип публикации: статья из журнала
Год издания: 2015
Идентификатор DOI: 10.1166/jnn.2015.9746
Ключевые слова: Nanodiamonds, Biodistribution, Particle Size, Intravenous Injection, Blood, Mammals, Radioactivity, Average size, Biodistributions, BSA molecules, Detonation nanodiamonds, Intravenous injections, Physiological solution, Radioactivity distribution, Short-term distribution, nanodiamond, animal, antibody specificity, chemistry, intravenous drug administration, male, materials testing, mouse, tissue distribution, ultrastructure, viscera, Animals, Injections, Intravenous, Mice, Organ Specificity
Аннотация: The particle size is one of critical parameters influencing the biodistribution of detonation nanodiamonds (DND) after their administration into the body. As DNDs are prone to aggregation, the difference between their sizes in aqueous and physiological solutions has to be taken into account. Radioactive I-125-BSA molecules were covalently immobilized on DNDs divided in three fractions of different average size. The DND-BSA(I125) conjugates were intravenously administrated into adult mice and the particle allocation in the animal's organs and blood was evaluated based on the radioactivity distribution. We conclude that most of the conjugates were taken from the bloodstream and trapped in the liver and spleen. The short-term distribution pattern for all DNDs was similar regardless of size and practically unchanged with time. No significant clearance of the particles was observed for 4 h, but the presence of DNDs was detected in the blood. It was found that the largest particles tend to accumulate more into the liver as compared to the smaller ones. However, the size effect was not well pronounced for the studied size range.
Журнал: JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
Выпуск журнала: Vol. 15, Is. 2
Номера страниц: 1070-1075
ISSN журнала: 15334880
Место издания: VALENCIA
Издатель: AMER SCIENTIFIC PUBLISHERS
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