Сибирский федеральный университет

Тип публикации: статья из журнала

Год издания: 2016

Идентификатор DOI: 10.1134/S1062359016050095

Аннотация: The aim of this study was to establish the role of oxidative modification of proteins and redox status in the realization of apoptosis of MCF-7 breast adenocarcinoma cells during cultivation with the SH-group blocker N-ethylmaleimide (NEM) and the SH-group protector 1,4-dithioerythritol (DTE). The activation of apoptosis in MCF-7 breast adenocarcinoma cells was shown to be due to the irreversible modification of redox-sensitive protein molecules. The presence of DTE in the culture medium of cancer cells caused reversible glutathionylation of protein molecules and did not change the number of apoptotic MCF-7 cells.

Журнал: BIOLOGY BULLETIN

Выпуск журнала: Vol. 43, Is. 5

Номера страниц: 385-389

ISSN журнала: 10623590

Место издания: NEW YORK

Издатель: MAIK NAUKA/INTERPERIODICA/SPRINGER

• Shakhristova E.V. (Siberian State Medical University,Ministry of Health of the Russian Federation)
• Stepovaya E.A. (Siberian State Medical University,Ministry of Health of the Russian Federation)
• Nosareva O.L. (Siberian State Medical University,Ministry of Health of the Russian Federation)
• Yakushina V.D. (Siberian State Medical University,Ministry of Health of the Russian Federation)
• Ivanov V.V. (Siberian State Medical University,Ministry of Health of the Russian Federation)
• Novitsky V.V. (Siberian State Medical University,Ministry of Health of the Russian Federation)
• Ryazantseva N.V. (Siberian Federal University)

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