Сибирский федеральный университет

Тип публикации: статья из журнала

Год издания: 2017

Идентификатор DOI: 10.3390/molecules22060975

Ключевые слова: Aptamers, Drug delivery, Magnetic hyperthermia, Magnetic nanoparticles, Magnetodynamic therapy, Magnetophoresis

Аннотация: Current advances in targeted magnetic nanotheranostics are summarized in this review. Unique structural, optical, electronic and thermal properties of magnetic materials in nanometer scale are attractive in the field of biomedicine. Magnetic nanoparticles functionalized with therapeutic molecules, ligands for targeted delivery, fluorescent and other chemical agents can be used for cancer diagnostic and therapeutic purposes. High selectivity, small size, and low immunogenicity of synthetic nucleic acid aptamers make them attractive delivery agents for therapeutic purposes. Properties, production and functionalization of magnetic nanoparticles and aptamers as ligands for targeted delivery are discussed herein. In recent years, magnetic nanoparticles have been widely used in diagnostic methods, such as scintigraphy, single photon emission computed tomography (SPECT), positron emission tomography (PET), magnetic resonance imaging (MRI), and Raman spectroscopy. Therapeutic purposes of magnetic nanoconstructions are also promising. They are used for effective drug delivery, magnetic mediated hypertermia, and megnetodynamic triggering of apoptosis. Thus, magnetic nanotheranostics opens a new venue for complex differential diagnostics, and therapy of metastatic cancer. © 2017 by the authors.

Журнал: Molecules

Выпуск журнала: Vol. 22, Is. 6

Номера страниц: 975

ISSN журнала: 14203049

Издатель: MDPI AG

• Belyanina I. (Krasnoyarsk State Medical University named after prof. V.F. Voino-Yaseneckii, Krasnoyarsk, Russian Federation)
• Kolovskaya O. (Krasnoyarsk State Medical University named after prof. V.F. Voino-Yaseneckii, Krasnoyarsk, Russian Federation, Federal Research Center, KSC Siberian Branch of Russian Academy of Science, Krasnoyarsk, Russian Federation)
• Zamay S. (Federal Research Center, KSC Siberian Branch of Russian Academy of Science, Krasnoyarsk, Russian Federation)
• Gargaun A. (Independent Researcher Vancouver, Vancouver, BC, Canada)
• Zamay T. (Krasnoyarsk State Medical University named after prof. V.F. Voino-Yaseneckii, Krasnoyarsk, Russian Federation, Federal Research Center, KSC Siberian Branch of Russian Academy of Science, Krasnoyarsk, Russian Federation)
• Kichkailo A. (Krasnoyarsk State Medical University named after prof. V.F. Voino-Yaseneckii, Krasnoyarsk, Russian Federation, Federal Research Center, KSC Siberian Branch of Russian Academy of Science, Krasnoyarsk, Russian Federation)

• Scopus