Тип публикации: статья из журнала
Год издания: 2018
Идентификатор DOI: 10.3892/ol.2018.8443
Ключевые слова: cell migration, cell proliferation, melanoma, microRNA-204-5p, microRNA-3065-5p
Аннотация: MicroRNA (miR)-204-5p was previously identified to be downregulated in melanoma compared with melanocytic nevi. This observation prompted a functional study on miR-204-5p and the newly-identified miR-3065-5p, two miRNAs suggested to be tumor-suppressive oncomiRs. Application of miR-204-5p mimics or inhibitors resulted in a decrease or increase, respectively, in melanoma cell proliferation and colony formation. miR-204-5p mimics hindered invasion, whereas miR-204-5p inhibitors stimulated cancer cell migration. Modulation of miR-3065-5p led to a decrease in melanoma cell proliferation, altered cell cycle distribution and increased expression levels of its target genes HIPK1 and ITGA1, possibly due to functional modifications identified in these cells. miR-204-5p and miR-3065-5p demonstrated antitumor capacities that may need to be taken into account in the development of melanoma treatment approaches.
Издание
Журнал: Oncology Letters
Выпуск журнала: Т. 15, № 6
Номера страниц: 8269-8280
ISSN журнала: 17921074
Персоны
- Palkina N. (Department of Pathophysiology,Krasnoyarsk State Medical University)
- Komina A. (Department of Pathophysiology,Krasnoyarsk State Medical University)
- Aksenenko M. (Department of Pathophysiology,Krasnoyarsk State Medical University)
- Ruksha T. (Department of Pathophysiology,Krasnoyarsk State Medical University)
- Moshev A. (Laboratory of Cell Molecular Physiology and Pathology,Federal Research Center,Krasnoyarsk Science Center of The Siberian Branch of The Russian Academy of Sciences)
- Savchenko A. (Laboratory of Cell Molecular Physiology and Pathology,Federal Research Center,Krasnoyarsk Science Center of The Siberian Branch of The Russian Academy of Sciences)
Вхождение в базы данных
Информация о публикациях загружается с сайта службы поддержки публикационной активности СФУ. Сообщите, если заметили неточности.