Сибирский федеральный университет

Тип публикации: статья из журнала

Год издания: 2015

Ключевые слова: Intravesical administration, Pharmacokinetics, Prospidine, prospidium chloride, animal experiment, Article, drug blood level, nonhuman, radioactivity, rat, systemic circulation

Аннотация: The pharmacokinetics of anticancer drug prospidine in intact rats has been studied upon intravesical administration at a dose of 100 mg/kg. It is established that the maximum concentration of the drug with specific radioactivity 10 ?curie 14C per 10 mg in the systemic circulation is achieved in 10 min after introduction and amounts to 140 ?g/mL. After 2 h, prospidine was present in the plasma in trace amounts. © 2015, Izdatel'stvo Meditsina. All rights reserved.

Журнал: Eksperimental'naya i Klinicheskaya Farmakologiya

Выпуск журнала: Vol. 78, Is. 4

Номера страниц: 22-24

• Selivanov S.P. (Siberian State Medical University, ul. Moskovskii Trakt 2, Tomsk, Russian Federation)
• Udut V.V. (E. D. Goldberg Research Institute of Pharmacology, prosp. Lenina 3, Tomsk, Russian Federation)
• Kladiev A.A. (TNK Biotechnological Company, Kostyanskii per. 9/10, Moscow, Russian Federation)
• Zaytseva M.A. (Institute of Toxicology, Federal Medico-Biological Agency of Russia, ul. Bekhtereva 1, St. Petersburg, Russian Federation)
• Udut E.V. (E. D. Goldberg Research Institute of Pharmacology, prosp. Lenina 3, Tomsk, Russian Federation)
• Shabunina T.I. (Siberian State Medical University, ul. Moskovskii Trakt 2, Tomsk, Russian Federation)
• Gurto R.V. (E. D. Goldberg Research Institute of Pharmacology, prosp. Lenina 3, Tomsk, Russian Federation)
• Bryushinina O.S. (E. D. Goldberg Research Institute of Pharmacology, prosp. Lenina 3, Tomsk, Russian Federation)

• Scopus