Сибирский федеральный университет

Тип публикации: статья из журнала

Год издания: 2022

Идентификатор DOI: 10.3390/bioengineering9030113

Ключевые слова: against fusarium fungi, biosafety, fungicidal biological preparation, metabolites, streptomyces tauricus

Аннотация: A biosafety study was carried out concerning the metabolites of Streptomyces tauricus strain 19/97 M. This strain is a promising producer of biological preparations and shows antagonistic properties against Fusarium fungi, which cause Fusarium wilt disease. The strain has a pronounced biological activity against conifers, cereals and legumes. The treatment of planting material reduces infections, increases germination and furthers plant productivity. Using metabolites, we understood the culture liquid separated by filtration after the cultivation of the strain. Animals of different taxonomic affiliations were used as test objects: (CBA × C57BI/6) F1 hybrid mice (Mus musculus) (warm-blooded organisms), Daphnia magna Straus (planktonic crustaceans) and the unicellular alga Chlorella vulgaris Beijer. In the study, we were guided by the test standards for acute oral toxicity and irritation to the skin, mucous membranes of the eyes and inhalation toxicity. The research results showed that the metabolites of the strain are not acutely toxic to organisms of different taxonomic levels. The metabolites of the strain do not have an irritating effect on the skin and mucous membranes of warm-blooded animals. Based on the studies carried out, metabolites can be used for creating a fungicidal biological preparation. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Журнал: Bioengineering

Выпуск журнала: Vol. 9, Is. 3

Номера страниц: 113

• Gaidasheva I.I. (Department of Biophysics, Siberian Federal University, Krasnoyarsk, 660041, Russian Federation)
• Shashkova T.L. (Department of Ecology and Environmental Management, Siberian Federal University, Krasnoyarsk, 660041, Russian Federation)
• Orlovskaya I.A. (Laboratory of Stem Cell Immunobiology, Research Institute of Fundamental and Clinical Immunology, Novosibirsk, 630099, Russian Federation)
• Gromovykh T.I. (Department of Biotechnology and Chemistry, Moscow Polytechnic University, Moscow, 107023, Russian Federation)

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