Тип публикации: статья из журнала
Год издания: 2017
Идентификатор DOI: 10.1007/s10517-017-3957-x
Ключевые слова: apoptosis, glutathione system, Jurkat tumor cells, oxidative protein modification, oxidative stressbuthionine sulfoximine, 5072-26-4, glutathione, 70-18-8, hydroxyl radical, 3352-57-6, protein, 67254-75-5
Аннотация: We compared changes in the redox status and intensity of oxidative modification of proteins in intact Jurkat tumor cells and cells cultured with buthionine sulfoximine, an inhibitor of the key enzyme of glutathione synthesis γ-glutamylcysteine synthetase. The glutathione system components play a role in modulation of the content of protein-bound glutathione, protein carbonyl derivatives, bityrosine, and oxidized tryptophan, and in dysregulation of apoptosis in Jurkat tumor cells. Inhibition of de novo synthesis of glutathione in Jurkat tumor cells was followed by accumulation of hydroxyl radical, a reduction in the level of protein-bound glutathione and oxidized tryptophan, and a rise in the concentration of protein carbonyl derivatives. These changes were accompanied by activation of programmed cell death. © 2017, Springer Science+Business Media, LLC, part of Springer Nature.
Издание
Журнал: Bulletin of Experimental Biology and Medicine
Выпуск журнала: Vol. 164, Is. 2
Номера страниц: 199-202
ISSN журнала: 00074888
Издатель: Springer New York LLC
Персоны
- Nosareva O.L. (Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russian Federation)
- Stepovaya E.A. (Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russian Federation)
- Ryazantseva N.V. (Siberian Federal University, Krasnoyarsk, Russian Federation, F. V. Voino-Yasentsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation, Krasnoyarsk, Russian Federation)
- Shakhristova E.V. (Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russian Federation)
- Egorova M.Y. (Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russian Federation)
- Novitsky V.V. (Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russian Federation)
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