Тип публикации: статья из журнала
Год издания: 2016
Идентификатор DOI: 10.1007/s10517-016-3397-z
Ключевые слова: beta-catenin, E-cadherin, thyroid cancer, ?-catenin
Аннотация: We compared the results of gene molecular and immunocytochemical studies of beta-catenin and E-cadherin in different variants of nodular thyroid disease (nodular colloid goiter, follicular thyroid adenocarcinoma, papillary thyroid cancer) and revealed changes of the function of the E-cadherin/beta-catenin complex leading to switching from adhesion function of beta-catenin in nodular colloid goiter to predominantly transcriptional activity in papillary carcinoma. The results confirm the important role of disturbances in E-cadherin-beta-catenin interactions in the mechanisms of malignant transformation of follicular epithelium.
Издание
Журнал: BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Выпуск журнала: Vol. 161, Is. 2
Номера страниц: 288-291
ISSN журнала: 00074888
Место издания: NEW YORK
Издатель: SPRINGER
Персоны
- Isaeva A.V. (Tomsk Research Institute of Oncology)
- Brynova O.V. (Moscow Municipal Oncological Hospital No. 62)
- Ryazantseva N.V. (Siberian Federal University)
- Litvinova L.S. (I. Kant Baltic Federal University)
- Pak Y.D. (Tomsk Regional Clinical Hospital)
- Zima A.P. (I. Kant Baltic Federal University)
- Saprina T.V. (Siberian State Medical University,Ministry of Health of the Russian Federation)
- Popov O.S. (Siberian State Medical University,Ministry of Health of the Russian Federation)
- Berezkina I.S. (Siberian State Medical University,Ministry of Health of the Russian Federation)
- Vasil'eva O.A. (Siberian State Medical University,Ministry of Health of the Russian Federation)
- Novitskii V.V. (Siberian State Medical University,Ministry of Health of the Russian Federation)
- Kasoyan K.T. (Russian Medical Academy of Postgraduate Education)
- Shabalova I.P. (Russian Medical Academy of Postgraduate Education)
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