Dietary buckwheat enhances sirtuin1 without calorie restriction | Научно-инновационный портал СФУ

Dietary buckwheat enhances sirtuin1 without calorie restriction

Тип публикации: статья из журнала

Год издания: 2020

Идентификатор DOI: 10.1016/j.jcs.2020.103004

Ключевые слова: calorie restriction, dietary buckwheat, male wistar rats, sirt1 expression

Аннотация: In the present investigation, the role of dietary intervention in male Wistar rats (n = 8, 3 groups) was studied to observe absolute sirtuin 1 (SIRT1) levels (expressed as ng mg−1 total protein) in serum, stomach, liver, and kidney. Dietary buckwheat at 30% (w/w) level of incorporation in the standard diet (Buckwheat Enriched Diet, BED) improved SIRT1 with values 0.933 ± 0.05, 210 ± 7, 63.26 ± 4, and 69.89 ± 3 in serum, stomach, liver, and kidney respectively when compared to the respective control values of 0.536 ± 0.03, 156 ± 23.3, 31.07 ± 2 and 47.11 ± 4. Moreover, BED though isocaloric to CR diet, led to weight gain (g) by 63.11 ± 3.8, ca. 10%, and 40% higher than control (56.27 ± 5.6) and CR (45.05 ± 4.1) diet groups. A marked rise in Feed Efficiency Ratio (FER) by ca. 37% while a 30% decrease in Feed Conversion Ratio (FCR) was observed for the BED group which supports unexpected weight gain in rats post-dietary intervention. The results justify the superior nutritional profile of buckwheat laden with essential nutrients, essential proteins, and bioactives. In contrast, Calorie Restriction (CR) resulted in a decline of the total protein content in circulation by 19%, while reduction of total protein in stomach, liver, and kidney was estimated to be 95%, 35.2%, and 27% respectively though SIRT1 values were comparatively the highest in all the samples studied. A 30-fold enhancement of SIRT1 in stomach post CR is presumed to counter enhanced stress in gastric tissues. Therefore, mild to moderate expression of SIRT1 may confer beneficial effects such as delayed aging and stress resistance but exceedingly high SIRT1 may evoke increased oxidative stress. © 2020 Elsevier Ltd

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Издание

Журнал: Journal of Cereal Science

Выпуск журнала: Vol. 94

ISSN журнала: 07335210

Издатель: Academic Press103004

Авторы

  • Pande Shubhra (Siberian Fed Univ, Inst Fundamental Biol & Biotechnol, Dept Biophys, Lab Bioluminescent Biotechnol, Svobodny Prospect 79, Krasnoyarsk 660041, Russia; Krasnoyarsk State Med Univ, Res Inst Mol Med & Pathobiochem, P Zheleznyaka 1, Krasnoyarsk 660022, Russia)
  • Ranjan Rajeev (Siberian Fed Univ, Inst Fundamental Biol & Biotechnol, Dept Biophys, Lab Bioluminescent Biotechnol, Svobodny Prospect 79, Krasnoyarsk 660041, Russia)
  • Shuvaev Anton N. (Krasnoyarsk State Med Univ, Res Inst Mol Med & Pathobiochem, P Zheleznyaka 1, Krasnoyarsk 660022, Russia)
  • Malinovskaya Natalia A. (Krasnoyarsk State Med Univ, Res Inst Mol Med & Pathobiochem, P Zheleznyaka 1, Krasnoyarsk 660022, Russia)
  • Ryazanova Maria (Siberian Fed Univ, Inst Fundamental Biol & Biotechnol, Dept Biophys, Lab Bioluminescent Biotechnol, Svobodny Prospect 79, Krasnoyarsk 660041, Russia)
  • Salmina Alla B. (Krasnoyarsk State Med Univ, Res Inst Mol Med & Pathobiochem, P Zheleznyaka 1, Krasnoyarsk 660022, Russia; Krasnoyarsk State Med Univ, Dept Biochem Med Pharmaceut & Toxicol Chem, P Zheleznyaka 1, Krasnoyarsk 660022, Russia)
  • Kolenchukova Oksana A. (Siberian Fed Univ, Inst Fundamental Biol & Biotechnol, Dept Biophys, Lab Bioluminescent Biotechnol, Svobodny Prospect 79, Krasnoyarsk 660041, Russia; Sci Res Inst Med Problems North, P Zheleznyaka 3g, Krasnoyarsk 660022, Russia)
  • Kratasyuk Valentina A. (Siberian Fed Univ, Inst Fundamental Biol & Biotechnol, Dept Biophys, Lab Bioluminescent Biotechnol, Svobodny Prospect 79, Krasnoyarsk 660041, Russia; Fed Res Ctr Krasnoyarsk Sci Ctr SB RAS, Inst Biophys SB RAS, Akademgorodok 50-50, Krasnoyarsk 660036, Russia)

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