Тип публикации: статья из журнала
Год издания: 2020
Идентификатор DOI: 10.31857/S0233475520010090
Ключевые слова: cisplatin, apoptosis, arabinogalactan, erlich ascites carcinoma, mechanocomposites
Аннотация: Cisplatin is an effective anticancer drug used to treat various types of cancer. The main disadvantage of the drug is its high toxicity. To reduce the toxic effect of cisplatin, we conjugated it with arabinogalactan, which is able to form soluble globules and bind poorly soluble pharmacological compounds by confining them inside spheroidal globules. In this study we compared the biological effect and mechanism of action of cisplatin and its complex with arabinogalactan (AG-Pt) on the growth of Ehrlich ascites carcinoma in vivo. The results showed that conjugates of arabinogalactan with platinum exerted a strong antitumor effect despite the fact that the dose of cisplatin in the composition of the conjugates was reduced 10-fold. At the same time, the conjugates of arabinogalactan with platinum were virtually nontoxic. The mechanism of action of cisplatin and its conjugates was almost the same and was associated with the induction of apoptosis of tumor cells. Apparently, a decrease in the toxicity and an increase in the effectiveness of the cisplatin conjugates with arabinogalactan compared with cisplatin is related with a more efficient accumulation of the conjugates in tumor cells that possess asialoglycoprotein receptors mediating the conjugate entry into the cells. © 2020 Russian Academy of Sciences, Institute of Archaeology. All rights reserved.
Журнал: Biologicheskie Membrany
Выпуск журнала: Vol. 37, Is. 1
Номера страниц: 69-75
ISSN журнала: 02334755
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