Сибирский федеральный университет

Тип публикации: статья из журнала

Год издания: 2008

Ключевые слова: anticoagulant agent, arabinogalactan, blood clotting factor 10a, galactan, plant extract, thrombin, article, bark, blood clotting, Cedrus, chemistry, drug antagonism, drug effect, human, in vitro study, Anticoagulants, Blood Coagulation, Factor Xa, Galactans, Humans, Plant Bark, Plant Extracts

Аннотация: We have studied in vitro the ability of the Siberian cedar crust (SCC) extract (Pinus sibirica Du Tour) and arabinogalactan sulphate (AGS) extracted from wood of Siberiam pine-tree (Larix sibirica Ledeb.) to increase the human blood plasma coagulation time and also to inhibit the amydolytic activity of thrombin (aIIa) and the coagulation factor Xa (aXa). A method has been developed by means of which SCC increases the aXa activity by a factor of 3.7 and the aIIa activity by a factor of 2.5. The AGS preparation increased the blood plasma coagulation time in the test for activated partial thromboplastin time. An effective concentration, at which the time of plasma coagulation was increased by a factor of 2 (in comparison to the control) was 2.94 ± 0.33 mg/ml. AGS did not exhibit the ability to inhibit the Xa activity.

Журнал: Eksperimental'naya i Klinicheskaya Farmakologiya

Выпуск журнала: Vol. 71, Is. 4

Номера страниц: 30-34

• Drozd N.N. (Laboratory of Hemostasis Pathology and Pharmacology, Scientific Hematological Center, Russian Academy of Medical Sciences, Novo-Zykovskii proezd 4a, Moscow, 125167, Russian Federation)
• Kuznetsova S.A. (Department of Catalytical Chemistry of Carbon and Biomass, Institute of Chemistry and Chemical Technology, Russian Academy of Sciences, ul. Karla Marksa 42, Krasnoyarsk, 660049, Russian Federation)
• Lapikova E.S. (Laboratory of Hemostasis Pathology and Pharmacology, Scientific Hematological Center, Russian Academy of Medical Sciences, Novo-Zykovskii proezd 4a, Moscow, 125167, Russian Federation)
• Davydova A.I. (Laboratory of Hemostasis Pathology and Pharmacology, Scientific Hematological Center, Russian Academy of Medical Sciences, Novo-Zykovskii proezd 4a, Moscow, 125167, Russian Federation)
• Makarov V.A. (Laboratory of Hemostasis Pathology and Pharmacology, Scientific Hematological Center, Russian Academy of Medical Sciences, Novo-Zykovskii proezd 4a, Moscow, 125167, Russian Federation)
• Kuznetsov B.N. (Department of Catalytical Chemistry of Carbon and Biomass, Institute of Chemistry and Chemical Technology, Russian Academy of Sciences, ul. Karla Marksa 42, Krasnoyarsk, 660049, Russian Federation)
• Butylkina A.I. (Department of Catalytical Chemistry of Carbon and Biomass, Institute of Chemistry and Chemical Technology, Russian Academy of Sciences, ul. Karla Marksa 42, Krasnoyarsk, 660049, Russian Federation)
• Vasil'eva N.Yu. (Department of Organic Chemistry, Siberian Federal University, Svobodhyi pr. 79, Krasnoyarsk, 660041, Russian Federation)
• Skvortsova G.P. (Department of Catalytical Chemistry of Carbon and Biomass, Institute of Chemistry and Chemical Technology, Russian Academy of Sciences, ul. Karla Marksa 42, Krasnoyarsk, 660049, Russian Federation)

• Scopus