Тип публикации: статья из журнала
Год издания: 2008
Идентификатор DOI: 10.1007/s10517-008-0091-9
Ключевые слова: microencapsulation, rubomycin, absorbable polymers, polyhydroxybutyrate, Ehrlich's ascitic carcinoma, poly(3 hydroxybutyric acid), polymer, animal cell, animal experiment, animal model, antineoplastic activity, article, Bagg albino mouse, cancer inhibition, cancer mortality, cancer survival, controlled study, drug delivery system, Ehrlich ascites tumor, mouse, nonhuman, polymerization, survival rate, tumor cell, tumor volume, Absorption, Animals, Antibiotics, Antineoplastic, Carcinoma, Ehrlich Tumor, Daunorubicin, Hydroxybutyrates, Mice, Mice, Inbred BALB C, Microspheres, Polyesters, Mus
Аннотация: An experimental dosage form of rubomycin is developed: the drug is incorporated in absorbable polymeric (polyhydroxybutyrate) matrix in the form of microparticles. Antitumor efficiency of this rubomycin dosage form was studied in laboratory mice with transplanted Ehrlich ascitic carcinoma. Rubomycin deposited in polymeric microparticles exhibited pronounced antitumor activity, inhibited the proliferative activity of Ehrlich ascitic carcinoma, and improved survival of mice with tumors. This dosage form of the drug can be used for local injections.
Издание
Журнал: BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Выпуск журнала: Vol. 145, Is. 3
Номера страниц: 358-361
ISSN журнала: 00074888
Место издания: NEW YORK
Издатель: SPRINGER
Персоны
- Shishatskaya E.I. (Institute of Biophysics, Siberian Branch of the Russian Academy of Sciences)
- Voinova O.N. (Institute of Biophysics, Siberian Branch of the Russian Academy of Sciences)
- Khlebopros R.G. (Institute of Biophysics, Siberian Branch of the Russian Academy of Sciences)
- Goreva A.V. (Siberian Federal University)
- Volova T.G. (Siberian Federal University)
- Inzhevatkin E.V. (Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of Science)
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