Aptamer-Conjugated Superparamagnetic Ferroarabinogalactan Nanoparticles for Targeted Magnetodynamic Therapy of Cancer : научное издание | Научно-инновационный портал СФУ

Aptamer-Conjugated Superparamagnetic Ferroarabinogalactan Nanoparticles for Targeted Magnetodynamic Therapy of Cancer : научное издание

Тип публикации: статья из журнала

Год издания: 2020

Идентификатор DOI: 10.3390/cancers12010216

Ключевые слова: aptamers, arabinogalactan, superparamagnetic ferroarabinogalactans, drug delivery, magnetodynamic therapy, magnetically induced cell disruption, magnetic resonance imaging

Аннотация: Nanotechnologies involving physical methods of tumor destruction using functional oligonucleotides are promising for targeted cancer therapy. Our study presents magnetodynamic therapy for selective elimination of tumor cells in vivo using DNA aptamer-functionalized magnetic nanoparticles exposed to a low frequency alternating magnetic field. We developed an enhanced targeting approach of cancer cells with aptamers and arabinogalactan. Aptamers to fibronectin (AS-14) and heat shock cognate 71 kDa protein (AS-42) facilitated the delivery of the nanoparticles to Ehrlich carcinoma cells, and arabinogalactan (AG) promoted internalization through asialoglycoprotein receptors. Specific delivery of the aptamer-modified FeAG nanoparticles to the tumor site was confirmed by magnetic resonance imaging (MRI). After the following treatment with a low frequency alternating magnetic field, AS-FeAG caused cancer cell death in vitro and tumor reduction in vivo. Histological analyses showed mechanical disruption of tumor tissues, total necrosis, cell lysis, and disruption of the extracellular matrix. The enhanced targeted magnetic theranostics with the aptamer conjugated superparamagnetic ferroarabinogalactans opens up a new venue for making biocompatible contrasting agents for MRI imaging and performing non-invasive anti-cancer therapies with a deep penetrated magnetic field.

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Издание

Журнал: CANCERS

Выпуск журнала: Vol. 12, Is. 1

Место издания: BASEL

Авторы

  • Kolovskaya Olga S. (Russian Acad Sci, Siberian Branch, Krasnoyarsk Sci Ctr, Fed Res Ctr, Krasnoyarsk 660036, Russia; Krasnoyarsk State Med Univ, Fac Med, Lab Biomol & Med Technol, Krasnoyarsk 660022, Russia)
  • Zamay Tatiana N. (Krasnoyarsk State Med Univ, Fac Med, Lab Biomol & Med Technol, Krasnoyarsk 660022, Russia)
  • Zamay Galina S. (Russian Acad Sci, Siberian Branch, Krasnoyarsk Sci Ctr, Fed Res Ctr, Krasnoyarsk 660036, Russia; Krasnoyarsk State Med Univ, Fac Med, Lab Biomol & Med Technol, Krasnoyarsk 660022, Russia)
  • Babkin Vasily A. (Russian Acad Sci, Siberian Branch, Irkutsk Inst Chem, Irkutsk 664033, Russia)
  • Medvedeva Elena N. (Russian Acad Sci, Siberian Branch, Irkutsk Inst Chem, Irkutsk 664033, Russia)
  • Neverova Nadezhda A. (Russian Acad Sci, Siberian Branch, Irkutsk Inst Chem, Irkutsk 664033, Russia)
  • Kirichenko Andrey K. (Krasnoyarsk State Med Univ, Fac Med, Lab Biomol & Med Technol, Krasnoyarsk 660022, Russia)
  • Zamay Sergey S. (Russian Acad Sci, Siberian Branch, Krasnoyarsk Sci Ctr, Fed Res Ctr, Krasnoyarsk 660036, Russia; Russian Acad Sci, Siberian Branch, Krasnoyarsk Sci Ctr, LV Kirensky Inst Phys SB RAS,Branch Fed Res Ctr, Krasnoyarsk 660036, Russia)
  • Lapin Ivan N. (Tomsk State Univ, Lab Adv Mat & Technol, Tomsk 634050, Russia)
  • Morozov Evgeny V. (Russian Acad Sci, Siberian Branch, Krasnoyarsk Sci Ctr, LV Kirensky Inst Phys SB RAS,Branch Fed Res Ctr, Krasnoyarsk 660036, Russia; Russian Acad Sci, Siberian Branch, Krasnoyarsk Sci Ctr, Inst Chem & Chem Technol SB RAS,Branch Fed Res Ct, Krasnoyarsk 660036, Russia)
  • Sokolov Alexey E. (Russian Acad Sci, Siberian Branch, Krasnoyarsk Sci Ctr, LV Kirensky Inst Phys SB RAS,Branch Fed Res Ctr, Krasnoyarsk 660036, Russia; Siberian Fed Univ, Sch Engn Phys & Radio Elect, Krasnoyarsk 660041, Russia)
  • Narodov Andrey A. (Krasnoyarsk State Med Univ, Fac Med, Lab Biomol & Med Technol, Krasnoyarsk 660022, Russia)
  • Fedorov Dmitri G. (Natl Inst Adv Ind Sci & Technol, Res Ctr Computat Design Adv Funct Mat CD FMat, Tsukuba, Ibaraki 3058568, Japan)
  • Tomilin Felix N. (Russian Acad Sci, Siberian Branch, Krasnoyarsk Sci Ctr, Fed Res Ctr, Krasnoyarsk 660036, Russia; Russian Acad Sci, Siberian Branch, Krasnoyarsk Sci Ctr, LV Kirensky Inst Phys SB RAS,Branch Fed Res Ctr, Krasnoyarsk 660036, Russia; Siberian Fed Univ, Sch Nonferrous Met & Mat Sci, Krasnoyarsk 660041, Russia)
  • Zabluda Vladimir N. (Russian Acad Sci, Siberian Branch, Krasnoyarsk Sci Ctr, LV Kirensky Inst Phys SB RAS,Branch Fed Res Ctr, Krasnoyarsk 660036, Russia)
  • Alekhina Yulia (Lomonosov Moscow State Univ, Dept Magnetism, Fac Phys, Moscow 119991, Russia)
  • Lukyanenko Kirill A. (Russian Acad Sci, Siberian Branch, Krasnoyarsk Sci Ctr, Fed Res Ctr, Krasnoyarsk 660036, Russia; Krasnoyarsk State Med Univ, Fac Med, Lab Biomol & Med Technol, Krasnoyarsk 660022, Russia; Siberian Fed Univ, Sch Fundamental Biol & Biotechnol, Krasnoyarsk 660041, Russia)
  • Glazyrin Yury E. (Russian Acad Sci, Siberian Branch, Krasnoyarsk Sci Ctr, Fed Res Ctr, Krasnoyarsk 660036, Russia; Krasnoyarsk State Med Univ, Fac Med, Lab Biomol & Med Technol, Krasnoyarsk 660022, Russia)
  • Svetlichnyi Valery A. (Tomsk State Univ, Lab Adv Mat & Technol, Tomsk 634050, Russia)
  • Berezovski Maxim V. (Univ Ottawa, Dept Chem & Biomol Sci, Ottawa, ON K1N 6N5, Canada)
  • Kichkailo Anna S. (Russian Acad Sci, Siberian Branch, Krasnoyarsk Sci Ctr, Fed Res Ctr, Krasnoyarsk 660036, Russia; Krasnoyarsk State Med Univ, Fac Med, Lab Biomol & Med Technol, Krasnoyarsk 660022, Russia)

Вхождение в базы данных

  • Web of Science Core Collection (цитирований 2)
  • Scopus (цитирований 2)

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