Сибирский федеральный университет

Тип публикации: статья из журнала

Год издания: 2014

Идентификатор DOI: 10.1007/s10973-013-3578-1

Ключевые слова: Betulin dipropionate, DSC, Enthalpy of fusion, Melting point, Ambient conditions, Arabinogalactan, Fumed silicas, Mechanical activation, Poly vinyl pyrrolidone, Mixtures

Аннотация: Melting of betulin dipropionate (3 beta,28-di-O-propionyl-lup-20(29)-lupene) of high purity (orthorhombic P2(1)2(1)2(1), a = 1.27409(2), b = 1.57316(3), c = 1.59810(3) nm) and its mixtures with four excipients was investigated with DSC and TG. Melting point is 163.6 A degrees C (a dagger(f) H = 33 kJ mol(-1)). Smaller values reported recently were measured for not pure samples. The melt of betulin dipropionate remains glassy under ambient conditions and does not crystallize during the second heating. In mixture with excipients (arabinogalactan, polyethylene glycol, polyvinylpyrrolidone, and fumed silica), the betulin dipropionate loses its crystal structure after mechanical activation.

Журнал: JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY

Выпуск журнала: Vol. 115, Is. 3

Номера страниц: 2521-2525

ISSN журнала: 13886150

Место издания: DORDRECHT

Издатель: SPRINGER

• Drebushchak V.A. (Novosibirsk State University)
• Shakhtshneider T.P. (Institute of Solid State Chemistry and Mechanochemistry,SB RAS)
• Drebushchak T.N. (Institute of Solid State Chemistry and Mechanochemistry,SB RAS)
• Mikhailenko M.A. (Institute of Solid State Chemistry and Mechanochemistry,SB RAS)
• Kuznetsova S.A. (Siberian Federal University)
• Malyar J.N. (Institute of Chemistry and Chemical Technology,SB RAS)

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