Сибирский федеральный университет

Тип публикации: статья из журнала

Год издания: 2009

Ключевые слова: fluoroquinolone, ciprofloxacin, sulfuric acid, crystal structure, hydrogen bonds

Аннотация: A new compound of C17H20FN3O32+center dot 2HSO(4)(-)center dot H2O [ciprofloxacindi-um bis(hydrosulfate) monohydrate], C17H18FN3O3 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid (CfH, ciprofloxacin) is obtained and its crystal structure is determined. The crystal contains CfH32+ and HSO4- ions and crystallization water molecules. Hydrogen (H3), which forms an intramolecular hydrogen bond with oxygen O2 of the carboxyl group, is attached to the carbonyl O1 atom. Hydrogen H4 of the carboxyl group is hydrogen bonded to the crystallization water molecule which links CfH32+ with two HSO4- groups by hydrogen bonds. Both H atoms at N3 of the piperazine ring form hydrogen bonds with two oxygen atoms of other HSO4- anions. Intramolecular hydrogen bonds of two types are present in the CfH32+ cation. One of them forms a six-membered ring, bonding O1 and O2 atoms, while the other, also enclosing a six-membered ring, links fluorine and carbon C14 atoms.

Журнал: JOURNAL OF STRUCTURAL CHEMISTRY

Выпуск журнала: Vol. 50, Is. 1

Номера страниц: 158-161

ISSN журнала: 00224766

Место издания: NEW YORK

Издатель: SPRINGER

• Vasiliev A.D. (Siberian Fed Univ, Krasnoyarsk, Russia)
• Golovnev N.N. (Siberian Fed Univ, Krasnoyarsk, Russia)
• Baidina I.A. (Russian Acad Sci, AV Nikolaev Inst Inorgan Chem, Siberian Div, Novosibirsk, Russia)

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