Сибирский федеральный университет

Перевод названия: AN EVALUATION OF THE METABOLIC CONDITION AND FUNCTIONAL ACTIVITY OF IMMUNE-COMPETENT CELLS IN CHILDREN WITH A RELAPSING HERPES VIRAL INFECTION

Тип публикации: статья из журнала

Год издания: 2003

Аннотация: Specific features of the immune response were studied (during the clinical remission period) in 40 children (aged 3 to 6) with a relapsing herpes viral infection (RHVI). The following was established: an in­creased relative and absolute quantity of lymphocytes, a reduced per­centage content of CD + and an increased absolute count of CD T in the peripheral blood. Changes in the immunity humoral chain mani­fested themselves by an increased content of class G immunoglobulins and of circulating immune complexes (CIC) in the blood serum. A re­duced quantity of phagocyting blood neutrophils was registered with the absorbing ability being preserved. Changes in the metabolic status of immune-competent cells were established; they were described by a high activity of the plastic exchange reaction, a tensed energetic poten­tial and a reduced glutathionc-recovery reaction modulating the prolif­erative activity of lymphocytes. A reduced reserve potential of oxygen-dependent biocenosis of neutrophyl granulocytes was detected in the peripheral blood. Obviously, the structural and metabolic changes in the blood lymphocytes as well as the abnormalities in the functional activity of neutrophyl granulocytes, observed during the clinical remis­sion period in the RHVI period, are a cause predetermining the relaps­es of the disease and can be regarded as a criterion for applying the immune rehabilitation.

Журнал: Клиническая лабораторная диагностика

Выпуск журнала: № 2

Номера страниц: 16

ISSN журнала: 08692084

Место издания: Москва

Издатель: Открытое акционерное общество Издательство Медицина

• Куртасова Л.М. (Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого)
• Савченко А.А. (Краевой центр по профилактике и борьбе со СПИДом, Красноярск)
• Шмидт А.Р. (Краевой центр по профилактике и борьбе со СПИДом, Красноярск)
• Чесноков А.Б. (Краевой центр по профилактике и борьбе со СПИДом, Красноярск)
• Ольховский И.А. (Краевой центр по профилактике и борьбе со СПИДом, Красноярск)

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