Сибирский федеральный университет

Тип публикации: статья из журнала

Год издания: 2015

Идентификатор DOI: 10.1016/j.mehy.2015.10.020

Ключевые слова: calcium ion, cytokine, immunoglobulin enhancer binding protein, microRNA, mitogen activated protein kinase, reactive nitrogen species, reactive oxygen metabolite, STAT3 protein, synapse receptor, Article, brain nerve cell, bystander signaling, calcium signaling, cell survival, central nervous system function, degenerative disease, DNA methylation, epigenetics, gene expression, histone modification, human, ion conductance, ionizing radiation, learning, memory, memory consolidation, memory formation, mental disease, nerve cell plasticity, nervous system development, neuromodulation, neurotransmission, nonhuman, signal transduction, synapse, biological model, bystander effect, cognition, computer simulation, evidence based medicine, male, metabolism, nerve cell, physiology, radiation dose, radiation response, Dose-Response Relationship, Radiation, Evidence-Based Medicine, Humans, Models, Neurological, Neurons, Radiation Dosage, Radiation, Ionizing, Reactive Oxygen Species

Аннотация: Possible scenarios of the influence of ionizing radiation on neural functioning and the CNS are suggested. We argue that the radiation-induced bystander mechanisms associated with Ca2+ flows, reactive nitrogen and oxygen species, and cytokines might lead to modulation of certain neuronal signaling pathways. The considered scenarios of conjugation of the bystander signaling and the neuronal signaling might result in modulation of certain synaptic receptors, neurogenesis, neurotransmission, channel conductance, synaptic signaling, different forms of neural plasticity, memory formation and storage, and learning. On this basis, corresponding new possible strategies for treating neurodegenerative deceases and mental disorders are proposed. The mechanisms considered might also be associated with neuronal survival and relevant to the treatment for brain injuries. At the same time, these mechanisms might be associated with detrimental effects and might facilitate the development of some neurological and psychiatric disorders. (C) 2015 Elsevier Ltd. All rights reserved.

Журнал: MEDICAL HYPOTHESES

Выпуск журнала: Vol. 85, Is. 6

Номера страниц: 723-735

ISSN журнала: 03069877

Место издания: EDINBURGH

Издатель: CHURCHILL LIVINGSTONE

• Zakhvataev Vladimir E. (Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Neuroinformat Dept, NL-6525 AJ Nijmegen, Netherlands; Siberian Fed Univ, Lab Biol Act Low Intens Factors, Krasnoyarsk 660041, Russia)

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