Frequency-contrast sensitivity of visual stimulus perception in patients with schizophrenia treated with atypical and typical antipsychotics

Тип публикации: статья из журнала

Год издания: 2014

Идентификатор DOI: 10.1134/S0362119714010150

Ключевые слова: contrast-frequency sensitivity, dopamine, Gabor elements, parvocellular and magnocellular visual channels, schizophrenia, serotonin, typical and atypical antipsychotics, visual perception

Аннотация: The effects of typical and atypical antipsychotics on the perception of visual stimuli that preferentially activate magnocellular or parvocellular visual channels have been studied. The threshold contrast sensitivity in healthy individuals and patients with schizophrenia has been recorded. The Gabor-like sinusoidal brightness gratings and spatial frequencies of 0.4, 3.6, and 17.9 cycles/degree were presented to the tested objects. The patients were divided into two groups, one receiving the therapy with atypical antipsychotics, and the other, with typical ones. The contrast sensitivity for low and medium spatial frequencies (i.e., for the stimuli corresponding to magnocellular channels) decreased compared to the norm. Note that the decrease in the contrast sensitivity for the low spatial frequencies in the patients treated with atypical antipsychotics is significantly more pronounced compared to the cohort that received typical antipsychotics. © 2014 Pleiades Publishing, Inc.

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Журнал: Human Physiology

Выпуск журнала: Vol. 40, Is. 1

Номера страниц: 35-39


  • Shoshina I.I. (Pavlov Institute of Physiology,Russian Academy of Sciences)
  • Shelepin Y.E. (Pavlov Institute of Physiology,Russian Academy of Sciences)
  • Semenova N.B. (Institute of Medical Problems of the North, Siberian Branch,Russian Academy of Sciences)

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