Сибирский федеральный университет

Тип публикации: статья из журнала

Год издания: 2017

Идентификатор DOI: 10.1007/s10517-017-3868-x

Ключевые слова: experimental tumor metastases in the lungs, leukemia L-1210, radioprotectors, radiotherapy, yeast RNA preparation

Аннотация: We studied radioprotective effects of a preparation based on yeast RNA and its influence on therapeutic efficiency of ionizing radiation against transplanted tumors. Parenteral administration of yeast RNA preparation to mice in a dose of 10 mg 1 h prior to exposure to ionizing γ-radiation (137Cs) in a lethal dose (LD80/30) increased 30-day survival by 66%; by day 80, 80% of animals survived (vs. 2.5% in the control). Whole-body exposure to ionizing γ-radiation in a dose of 7 Gy significantly increased the mean lifespan of mice with experimental lung metastases or intraperitoneally transplanted leukemia L-1210 by 42 and 20.8%, respectively. RNA preparation injected to the mice with tumors 1 h before irradiation did not affect the therapeutic efficiency of ionizing radiation or significantly potentiated it (in mice with transplanted leukemia L-1210). These results suggest that yeast RNA preparation protects healthy tissues during radiotherapy of malignant tumors. © 2017, Springer Science+Business Media, LLC.

Журнал: Bulletin of Experimental Biology and Medicine

Выпуск журнала: Vol. 163, Is. 5

Номера страниц: 639-642

ISSN журнала: 00074888

Издатель: Springer New York LLC

• Nikolin V.P. (Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russian Federation)
• Bogachev S.S. (Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russian Federation)
• Popova N.A. (Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russian Federation, Novosibirsk State University, Novosibirsk, Russian Federation)
• Tornuev Y.V. (Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russian Federation)
• Vinogradova E.V. (Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russian Federation)

• Scopus