Effect of ball-milling on the formation of betulin and betulin diacetate composites with polyethylene glycol | Научно-инновационный портал СФУ

Effect of ball-milling on the formation of betulin and betulin diacetate composites with polyethylene glycol

Тип публикации: доклад, тезисы доклада, статья из сборника материалов конференций

Конференция: International Conference on Fundamental Bases of Mechanochemical Technologies (FBMT); Russian Acad Sci, Serbian Branch, Inst Solid State Chem & Mechanochemistry, Novosibirsk, RUSSIA; Russian Acad Sci, Serbian Branch, Inst Solid State Chem & Mechanochemistry, Novosibirsk, RUSSIA

Год издания: 2019

Идентификатор DOI: 10.1016/j.matpr.2019.03.068

Ключевые слова: betulin, betulin diacetate, PEG, ball-milling, composite formation, amorphization, melting, crystallization

Аннотация: Betulin and betulin diacetate (BDA) composites with polyethylene glycol (PEG) were obtained by ball-milling. In case of betulin - PEG mixtures, there was almost complete amorphization under ball-milling. On the contrary, there were no significant changes Betulin and betulin diacetate (BDA) composites with polyethylene glycol (PEG) were obtained by ball-milling. In case of betulin - PEG mixtures, there was almost complete amorphization under ball-milling. On the contrary, there were no significant changes in the intensity of the reflections in the powder X-ray diffraction patterns for ball-milled mixtures of BDA with PEG. Dissolution of BDA in PEG melts formed at the contacts of particles under collisions with milling bodies leading to crystallization of the drug was suggested. An opportunity to dissolve BDA crystals in PEG melt followed by their crystallization was proven by DSC and hot stage optical microscopic observation. © 2019 Elsevier Ltd. All rights reserved.

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Издание

Журнал: MATERIALS TODAY-PROCEEDINGS

Выпуск журнала: Vol. 12, Part 1

Номера страниц: 78-81

ISSN журнала: 22147853

Место издания: AMSTERDAM

Издатель: ELSEVIER SCIENCE BV

Авторы

  • Shakhtshneider Tatyana P. (RAS, Inst Solid State Chem & Mechanochem, SB, Kutateladze,18, Novosibirsk 630128, Russia; Novosibirsk State Univ, Pirogov Str,2, Novosibirsk 630090, Russia)
  • Mikhailenko Mikhail A. (RAS, Inst Solid State Chem & Mechanochem, SB, Kutateladze,18, Novosibirsk 630128, Russia)
  • Drebushchak Valeri A. (Novosibirsk State Univ, Pirogov Str,2, Novosibirsk 630090, Russia; RAS, Sobolev Inst Geol & Mineral, SB, Lavrentiev Ave,3, Novosibirsk 630090, Russia)
  • Drebushchak Tatiana N. (RAS, Inst Solid State Chem & Mechanochem, SB, Kutateladze,18, Novosibirsk 630128, Russia; Novosibirsk State Univ, Pirogov Str,2, Novosibirsk 630090, Russia)
  • Malyard Yuri N. (RAS, Inst Chem & Chem Technol, SB, FRC,KSC, Akademgorodok,50-24, Krasnoyarsk, Russia; Siberian Fed Univ, Svobodny Pr,79-10, Krasnoyarsk 660041, Russia)
  • Kuznetsova Svetlana A. (RAS, Inst Chem & Chem Technol, SB, FRC,KSC, Akademgorodok,50-24, Krasnoyarsk, Russia; Siberian Fed Univ, Svobodny Pr,79-10, Krasnoyarsk 660041, Russia)

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