New composites of betulin esters with arabinogalactan as highly potent anti-cancer agents

Тип публикации: статья из журнала

Год издания: 2016

Идентификатор DOI: 10.1080/14786419.2015.1060591

Ключевые слова: betulin diacetate, betulin dipropionate, arabinogalactan, composites, solubility, anticancer activity

Аннотация: Betulin and its esters are the natural compounds with high in vitro cytotoxicity toward many cancer cells. However, the poor water solubility of these compounds has limited their applications. We prepared new composites of betulin esters using two methods, namely ball-milling of the mixtures of betulin esters with arabinogalactan and preparation of thin films of these mixtures by evaporating the aqueous solutions. These composites revealed higher water solubility as compared with the initial substances without losing the structural integrity and functionality. As a result, the new composites have shown much higher inhibitory effects against different cancer cell lines such as Ehrlich ascites carcinoma cells and lung carcinoma cells (A549) in comparison with the initial substances. The cell viability studies based on Annexin V and Propidium iodide probes have confirmed the high proapoptotic effect of betulin ester derivatives against cancer cells.

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Издание

Журнал: NATURAL PRODUCT RESEARCH

Выпуск журнала: Vol. 30, Is. 12

Номера страниц: 1382-1387

ISSN журнала: 14786419

Место издания: ABINGDON

Издатель: TAYLOR & FRANCIS LTD

Авторы

  • Shakhtshneider T.P. (Novosibirsk State University)
  • Spivak E.A. (Research Institute of Molecular Medicine and Pathobiochemistry,Krasnoyarsk State Medical University)
  • Mikhailenko M.A. (SB RAS,Institute of Solid State Chemistry and Mechanochemistry)
  • Boldyrev V.V. (Novosibirsk State University)
  • Kuznetsova S.A. (Siberian Federal University)
  • Zamay A.S. (Research Institute of Molecular Medicine and Pathobiochemistry,Krasnoyarsk State Medical University)
  • Malyar Y.N. (SB RAS,Institute of Chemistry and Chemical Technology)
  • Kuznetsov B.N. (Siberian Federal University)
  • Chesnokov N.V. (Siberian Federal University)
  • Zamay T.N. (Research Institute of Molecular Medicine and Pathobiochemistry,Krasnoyarsk State Medical University)

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