Screening and characterization of cocrystal formation between betulin and terephthalic acid : доклад, тезисы доклада | Научно-инновационный портал СФУ

Screening and characterization of cocrystal formation between betulin and terephthalic acid : доклад, тезисы доклада

Год издания: 2020

Идентификатор DOI: 10.1016/j.matpr.2019.12.096

Ключевые слова: betulin, terephthalic acid, co-grinding, cocrystal, solubility

Аннотация: The pharmaceutical cocrystals are nowdays intensively studied due to the improvements of solubility, stability, processability, etc. of the drugs. In this work, the cocrystals of betulin with terephthalic acid as a coformer were prepared by liquid-assisted grinding method. The formation of cocrystals was confirmed by powder X-ray diffraction, IR spectroscopy and thermal analysis methods. HPLC analysis showed that in the case of betulin - terephthalic acid cocrystals, solubility of betulin was significantly improved compared to the initial betulin as well as betulin from cocrystals with aliphatic dicarboxylic acids which were earlier prepared. (C) 2019 Elsevier Ltd. All rights reserved. Selection and peer-review under responsibility of the scientific committee of the III All-Russian Conference (with International Participation) "Hot Topics of Solid State Chemistry: From New Ideas to New Materials". The pharmaceutical cocrystals are nowdays intensively studied due to the improvements of solubility, stability, processability, etc. of the drugs. In this work, the cocrystals of betulin with terephthalic acid as a coformer were prepared by liquid-assisted grinding method. The formation of cocrystals was confirmed by powder X-ray diffraction, IR spectroscopy and thermal analysis methods. HPLC analysis showed that in the case of betulin - terephthalic acid cocrystals, solubility of betulin was significantly improved compared to the initial betulin as well as betulin from cocrystals with aliphatic dicarboxylic acids which were earlier prepared. © 2019 Elsevier Ltd.

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Издание

Журнал: MATERIALS TODAY-PROCEEDINGS

Выпуск журнала: Vol. 25

Номера страниц: 381-383

ISSN журнала: 22147853

Место издания: AMSTERDAM

Издатель: ELSEVIER

Авторы

  • Mikhailovskaya Anastasiya V. (RAS, Inst Solid State Chem & Mechanochem SB, Kutateladze Str 18, Novosibirsk 630128, Russia.; Novosibirsk State Univ, Pirogov Str 2, Novosibirsk 630090, Russia.)
  • Myz Svetlana A. (RAS, Inst Solid State Chem & Mechanochem SB, Kutateladze Str 18, Novosibirsk 630128, Russia.)
  • Bulina Natalia V. (RAS, Inst Solid State Chem & Mechanochem SB, Kutateladze Str 18, Novosibirsk 630128, Russia.; Novosibirsk State Univ, Pirogov Str 2, Novosibirsk 630090, Russia.)
  • Gerasimov Konstantin B. (RAS, Inst Solid State Chem & Mechanochem SB, Kutateladze Str 18, Novosibirsk 630128, Russia.)
  • Kuznetsova Svetlana A. (RAS, FRC KSC SB, Inst Chem & Chem Technol, Akademgorodok 50-24, Krasnoyarsk 660036, Russia.; Siberian Fed Univ, Svobodny Pr 79-10, Krasnoyarsk 660041, Russia.)
  • Shakhtshneider Tatyana P. (RAS, Inst Solid State Chem & Mechanochem SB, Kutateladze Str 18, Novosibirsk 630128, Russia.; Novosibirsk State Univ, Pirogov Str 2, Novosibirsk 630090, Russia.)

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