Сибирский федеральный университет

Тип публикации: статья из журнала

Год издания: 2015

Идентификатор DOI: 10.1007/s11094-015-1246-4

Ключевые слова: Siberian fir, Abies sibirica Ledeb, heparin, microcrystalline cellulose sulfate, antithrombin activity, Abies sibirica extract, antithrombin, blood clotting factor 10, cellulose sulfate, microcrystalline cellulose, plant extract, sulfur, unclassified drug, anticoagulation, Article, blood clotting, drug megadose, ex vivo study, in vitro study, molecular weight, nonhuman, plasma, wood

Аннотация: The anticoagulant activity of the microcrystalline cellulose sulfate (MCCS) extracted from the wood of Abies sibirica Ledeb (molecular weight 86,000, sulfur substitution level 1.63) were studied in vitro and ex vivo. The antithrombin activity was 87.4 +/- 0.7 U/mg and activity against activated factor X was 18.3 +/- 0.2 U/mg. S.c. administration of high doses (5, 20, and 40 mg/kg) of MCCS to rabbits increased plasma antithrombin activity. A cellulose sulfate dose of 10 mg/kg produced the same area under the pharmacodynamic curve for plasma antithrombin activity as unfractionated heparin (5 mg/kg).

Журнал: PHARMACEUTICAL CHEMISTRY JOURNAL

Выпуск журнала: Vol. 49, Is. 3

Номера страниц: 167-170

ISSN журнала: 0091150X

Место издания: NEW YORK

Издатель: SPRINGER

• Drozd N.N. (Hematology Scientific Center,Russian Ministry of Health)
• Savchik E.Y. (Hematology Scientific Center,Russian Ministry of Health)
• Miftakhova N.T. (Hematology Scientific Center,Russian Ministry of Health)
• Kuznetsova S.A. (Siberian Federal University)
• Vasil'eva N.Y. (Siberian Federal University)

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