Сибирский федеральный университет

Тип публикации: статья из журнала

Год издания: 2015

Идентификатор DOI: 10.1089/bio.2014.0035

Ключевые слова: DNA, plutonium, acute heart infarction, adult, aged, alcohol consumption, bank of biological materials, bladder cancer, blood, breast cancer, bronchus cancer, cell suspension, chromosome analysis, colon cancer, donor, echocardiography, electrocardiogram, employee, esophagus cancer, female, gamma radiation, health care facility, heart muscle necrosis, heart scintiscanning, human, human cell, human tissue, ionizing radiation, kidney cancer, leukocyte, long term exposure, male, occupational exposure, ovary cancer, pathophysiology, physical activity, priority journal, prostate cancer, radiation dose, radiation exposure, radiosensitivity, rectum cancer, Review, skin cancer, smoking, stomach cancer, thyroid cancer, tissue section, uterine cervix cancer, genetics, laboratory diagnosis, Neoplasms, normal human, organization and management, pathology, procedures, radiation response, risk factor, Russian Federation, Biological Specimen Banks, Healthy Volunteers, Humans, Radiation, Ionizing, Risk Factors, Russia, Specimen Handling

Аннотация: Collection and storage of biological specimens in biobanks aims to obtain and preserve samples of different kinds for biological and medical studies. Here we present a description of the Bank of Biological Materials (BBM) housed by the Seversk Biophysical Research Centre (SBRC; Seversk, Russia). The main goal of maintaining the BBM is to collect and store biological samples suitable for genetic studies of people exposed to long-term ionizing radiation. Currently, the collection includes 19,194 biological specimens obtained from 8105 donors, of whom 42.3% are diagnosed with malignant neoplasms, 28.7% are healthy residents of the city of Seversk, 18.8% are healthy employees of the Siberian Group of Chemical Enterprises (SGCE), and 10.2% are patients diagnosed with acute myocardial infarction. The donors were enrolled using the Regional Medical and Dosimetric Register database created by the SBRC. For each donor, DNA specimens were extracted from peripheral blood and tissues and cell suspensions for cytogenetic analysis were prepared routinely. The BBM's unique collection is suitable primarily for studies of individual radiosensitivity of humans (IRH), and genetic aspects of the pathophysiology of common human diseases, especially in populations exposed to long-term low-dose ionizing radiation. © Mary Ann Liebert, Inc.

Журнал: Biopreservation and Biobanking

Выпуск журнала: Vol. 13, Is. 2

Номера страниц: 72-78

• Takhauov R.M. (Seversk Biophysical Research Center, Russian Federal Medical and Biological Agency, Kommunistichesky av., 87, Seversk, Tomsk Region, Russian Federation)
• Karpov A.B. (Seversk Biophysical Research Center, Russian Federal Medical and Biological Agency, Kommunistichesky av., 87, Seversk, Tomsk Region, Russian Federation)
• Albach E.N. (Seversk Biophysical Research Center, Russian Federal Medical and Biological Agency, Kommunistichesky av., 87, Seversk, Tomsk Region, Russian Federation)
• Khalyuzova M.V. (Seversk Biophysical Research Center, Russian Federal Medical and Biological Agency, Kommunistichesky av., 87, Seversk, Tomsk Region, Russian Federation, National Research Tomsk State University, Tomsk, Russian Federation)
• Freidin M.B. (Seversk Biophysical Research Center, Russian Federal Medical and Biological Agency, Kommunistichesky av., 87, Seversk, Tomsk Region, Russian Federation)
• Litviakov N.V. (Seversk Biophysical Research Center, Russian Federal Medical and Biological Agency, Kommunistichesky av., 87, Seversk, Tomsk Region, Russian Federation, National Research Tomsk State University, Tomsk, Russian Federation)
• Sazonov A.E. (Seversk Biophysical Research Center, Russian Federal Medical and Biological Agency, Kommunistichesky av., 87, Seversk, Tomsk Region, Russian Federation)
• Isubakova D.S. (Seversk Biophysical Research Center, Russian Federal Medical and Biological Agency, Kommunistichesky av., 87, Seversk, Tomsk Region, Russian Federation)
• Bolshakov M.A. (National Research Tomsk State University, Tomsk, Russian Federation)
• Mezheritskiy S.A. (Seversk Biophysical Research Center, Russian Federal Medical and Biological Agency, Kommunistichesky av., 87, Seversk, Tomsk Region, Russian Federation)
• Mironova E.B. (Seversk Clinical Hospital of Siberian Federal Research and Clinical Center, Russian Federal Medical and Biological Agency, Seversk, Russian Federation)
• Semenova J.V. (Seversk Clinical Hospital of Siberian Federal Research and Clinical Center, Russian Federal Medical and Biological Agency, Seversk, Russian Federation)
• Nekrasov G.B. (Seversk Clinical Hospital of Siberian Federal Research and Clinical Center, Russian Federal Medical and Biological Agency, Seversk, Russian Federation)
• Izosimov A.S. (Seversk Clinical Hospital of Siberian Federal Research and Clinical Center, Russian Federal Medical and Biological Agency, Seversk, Russian Federation)
• Gagarin A.A. (Seversk Clinical Hospital of Siberian Federal Research and Clinical Center, Russian Federal Medical and Biological Agency, Seversk, Russian Federation)
• Brendakov R.V. (Seversk Biophysical Research Center, Russian Federal Medical and Biological Agency, Kommunistichesky av., 87, Seversk, Tomsk Region, Russian Federation)
• Maksimov D.E. (Seversk Biophysical Research Center, Russian Federal Medical and Biological Agency, Kommunistichesky av., 87, Seversk, Tomsk Region, Russian Federation)
• Ermolaev Y.D. (Seversk Clinical Hospital of Siberian Federal Research and Clinical Center, Russian Federal Medical and Biological Agency, Seversk, Russian Federation)

• Scopus