An in vivo study of osteoplastic properties of resorbable poly-3-hydroxybutyrate in models of segmental osteotomy and chronic osteomyelitis

Тип публикации: статья из журнала

Год издания: 2014

Идентификатор DOI: 10.3109/21691401.2013.816312

Ключевые слова: polymer of 3-hydroxybutyric acid, bone substitute, P3HB, hydroxyapatite, 3D implants, reconstructive osteogenesis, histological analysis and radiography, 3D implants, Bone substitute, Histological analysis and radiography, Hydroxyapatite, P3HB, Polymer of 3-hydroxybutyric acid, Reconstructive osteogenesis, Bacteria, Bone, Filling, Hydroxyapatite, 3-hydroxybutyric acid, Bone substitutes, Histological analysis, Osteogenesis, P3HB, Biodegradable polymers, cilastatin plus imipenem, hydroxyapatite, poly(3 hydroxybutyric acid), biomaterial, hydroxybutyric acid, poly-beta-hydroxybutyrate, polyester, adult, animal experiment, animal model, animal tissue, Article, bone allograft, bone defect, bone development, bone graft, bone regeneration, bone remodeling, bone structure, chronic osteomyelitis, computer assisted radiography, contact angle, controlled study, degradation, female, Haversian canal, histopathology, hyperemia, in vivo study, male, microscopy, nonhuman, osteoblast, osteotomy, porosity, postoperative period, rat, skin injury, Staphylococcus infection, surface property, surgical wound, tissue growth, wettability, wound healing, animal, chronic disease, disease model, drug effects, metabolism, microbiology, osteomyelitis, pathophysiology, physiology, prostheses and orthoses, Staphylococcus aureus, Wistar rat, Animals, Biocompatible Materials, Chronic Disease, Disease Models, Animal, Female, Hydroxybutyrates, Osteogenesis, Osteomyelitis, Osteotomy, Polyesters, Prostheses and Implants, Rats, Rats, Wistar, Staphylococcus aureus

Аннотация: A series of 3D implants and filling materials prepared from powdered biodegradable polymers, polyhydroxyalkanoates (PHAs), have been designed for the purposes of reparative osteogenesis. The 3D implants are made of resorbable polymer of hydroxybutyric acid (poly-3-hydroxybutyrate, P3HB) and a composite of this polymer with hydroxyapatite (HA) (P3HB/HA). The properties of the implants were studied in vivo in a model of segmental osteotomy and compared with commercial material Bio-Oss (R). All implants containing P3HB as the main component facilitate reconstructive osteogenesis. P3HB and P3HB/HA show pronounced osteoplastic properties; their in vivo degradation is slow and corresponds to the growth of a new bone tissue, facilitating normal reparative osteogenesis. Also, powdered P3HB and P3HB/tienam can be used as filling materials for osteoplasty of bone cavities infected by Staphylococcus aureus. Biodegradable 3D implants and P3HB-based filling materials show pronounced osteoplastic properties and degrade in vivo at a slow rate, enabling normal reparative osteogenesis.

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Издание

Журнал: ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY

Выпуск журнала: Vol. 42, Is. 5

Номера страниц: 344-355

ISSN журнала: 21691401

Место издания: LONDON

Издатель: INFORMA HEALTHCARE

Авторы

  • Shishatskaya E.I. (Siberian Federal University)
  • Shumilova A.A. (Siberian Federal University)
  • Kamendov I.V. (Krasnoyarsk Dental Research Center for Diabetes Mellitus Problems)
  • Starosvetsky S.I. (Krasnoyarsk Dental Research Center for Diabetes Mellitus Problems)
  • Vinnik Y.S. (Krasnoyarsk State Medical University)
  • Markelova N.N. (Krasnoyarsk State Medical University)
  • Shageev A.A. (Krasnoyarsk State Medical University)
  • Khorzhevsky V.A. (Krasnoyarsk State Medical University)
  • Peryanova O.V. (Krasnoyarsk State Medical University)

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