Сибирский федеральный университет

Тип публикации: статья из журнала

Год издания: 2010

Ключевые слова: Anthocyanidins, Anticoagulant activity, Arabinogalactan sulfate, Aspen, Birch, Cedar, Dihydroquercetin sulfate, Fir, Larch, Methylcellulose sulfate, Microcrystalline cellulose sulfate, Pine, Spruce, Wheat straw, methylcellulose, proanthocyanidin derivative, taxifolin, anthocyanin, anticoagulant agent, antithrombin, plant extract, quercetin, anticoagulation, article, bark, drug activity, Larix, wheat, wood, Abies, analogs and derivatives, blood clotting, Cedrus, chemistry, dose response, drug effects, human, Anthocyanins, Anticoagulants, Antithrombins, Blood Coagulation, Dose-Response Relationship, Drug, Humans, Picea, Plant Bark, Plant Extracts, Triticum

Аннотация: We have investigated in vitro the anticoagulant (AC) activity of proanthocyanidins from the bark of birch, cedar, spruce, pine, and larch; sulfated arabinogalantan and dihydroquercetin from larch wood; extracts from birch, cedar, and spruce; microcrystalline cellulose (MCC) from aspen and fir wood and wheat straw; and methylcellulose (MC) from aspen wood. The AC properties of the investigated substances are related mostly to their antithrombin activity. The AC activity increases with the content of sulfur in MCC of wheat straw, MC of aspen wood, and arabinogalantan of larch wood. The maximum AC activity was observed in samples of sulfated MCC from fir wood and wheat straw. Their antithrombin activity (134 ± 8 and 96 ± 6, respectively) is worth of carrying out model tests in vivo.

Журнал: Eksperimental'naya i Klinicheskaya Farmakologiya

Выпуск журнала: Vol. 73, Is. 6

Номера страниц: 14-18

• Drozd N.N.
• Kuznetsova S.A.
• Miftakhova N.T.
• Makarov V.A.
• Vasil'eva N.Yu.
• Levdanskii A.V.
• Butylkina A.I.

• Scopus