Characterization of polymeric microparticles based on resorbable polyesters of oxyalkanoic acids as a platform for deposition and delivery of drugs

Тип публикации: статья из журнала

Год издания: 2012

Идентификатор DOI: 10.1134/S0965545X12020022

Ключевые слова: 3-Hydroxybutyrate, 3-Hydroxyvalerate, Chemical compositions, Drug release, In-vitro, Mass fraction, Mathematical descriptions, Micro-particles, Phosphate buffers, Polyhydroxyalkanoates, Preparation parameters, Preparation technique, Resorbable, Copolymers, Emulsification, Esters, Mixing, Nanocomposites, Polyesters

Аннотация: The effect of the preparation technique (chemical composition of a polymer, type and method of emulsion mixing, and molecular mass of a drug) on the yield, structure, and size of microparticles obtained from resorbable polyesters of microbiological origin, polyhydroxyalkanoates, is studied. It is found that the concentration of the polymer solution and the method of emulsion mixing are the most significant factors affecting the diameter of microparticles based on polyhydroxyalkanoates; the surface structure of particles depends to a higher extent on the chemical composition of the polymer. The family of microparticles from 100-200 nm to 50-70 mu m in diameter is synthesized. It is shown that the rate of drug release from microparticles in vitro into the medium is higher in the case of 3-hydroxybutyrate copolymers with 3-hydroxyvalerate than in the case of the homopolymer of 3-hydroxybutyrate. This parameter increases with the content of 3-hydroxyvalerate units in the copolymer and the porosity and mass fraction of the drug in particles with a decrease in their sizes. For in vitro systems containing a phosphate buffer, variation in the preparation parameters makes it possible to obtain microparticles with various characteristics suitable for deposition of drugs. For microparticles obtained from polyhydroxyalkanoates and having different diameters, the mathematical description of the kinetics of drug release from the polymer matrix is provided.

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Издание

Журнал: POLYMER SCIENCE SERIES A

Выпуск журнала: Vol. 54, Is. 2

Номера страниц: 94-105

ISSN журнала: 0965545X

Место издания: NEW YORK

Издатель: MAIK NAUKA/INTERPERIODICA/SPRINGER

Авторы

  • Goreva A.V. (Russian Acad Sci, Siberian Branch, Inst Biophys, Krasnoyarsk 660036, Russia; MIT, Cambridge, MA 02139 USA)
  • Shishatskaya E.I. (Russian Acad Sci, Siberian Branch, Inst Biophys, Krasnoyarsk 660036, Russia; Siberian Fed Univ, Inst Fundamental Biol & Biotechnol, Krasnoyarsk 660041, Russia)
  • Volova T.G. (Russian Acad Sci, Siberian Branch, Inst Biophys, Krasnoyarsk 660036, Russia; Siberian Fed Univ, Inst Fundamental Biol & Biotechnol, Krasnoyarsk 660041, Russia)
  • Sinskey A.J. (MIT, Cambridge, MA 02139 USA)

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