Stoichiometric modeling of oxygen transportation through the surface of isolated perfused rat liver

Тип публикации: статья из журнала

Год издания: 2016

Идентификатор DOI: 10.17537/2016.11.263

Ключевые слова: Hypoxia, Perfusion, Stoichiometric modeling, The oxygen transportation

Аннотация: Stoichiometric modeling allows analyzing the features of metabolism both the cell populations and the holistic isolated organs. In this paper, one of the stoichiometric modeling methods, Flux Balance Analysis, was used to investigate the mechanisms of oxygen transportation through the surface of the isolated perfused rat liver at various oxygenation conditions. It is shown that the oxygen intake through the surface of the isolated perfused liver is associated with energy consumption. © 2016 Shadrin K.V., Pakhomova V.G., Rupenko A.P., Kryukova O.V., Khlebopros R.G.

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Издание

Журнал: Mathematical Biology and Bioinformatics

Выпуск журнала: Vol. 11, Is. 2

Номера страниц: 263-277

ISSN журнала: 19946538

Авторы

  • Shadrin K.V. (Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of Science, Russian Federation, Krasnoyarsk State Medical University, Russian Federation)
  • Pakhomova V.G. (Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of Science, Russian Federation)
  • Rupenko A.P. (Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of Science, Russian Federation)
  • Kryukova O.V. (Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of Science, Russian Federation)
  • Khlebopros R.G. (Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of Science, Russian Federation, Siberian Federal University, Russian Federation, Russian Academy of Science Siberian Branch Institute of Biophysics, Russian Federation)

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