Тип публикации: глава из книги
Год издания: 2014
Ключевые слова: Drug delivery, Implants, Particles, PHAs, biomedical studies, Surgical sutures
Аннотация: The chapter describes research of biomedical applications of experimental polymer devices prepared from polyhydroxyalkanoates (PHAs) with different chemical structure in the Institute of Biophysics SB RAS and Siberian Federal University (Krasnoyarsk, Russia) between 2000 and 2012. The high-purity PHA specimens were investigated and then used to prepare surgical sutures, 2D and 3D dense and porous matrices, microparticles, monofilament fibers, fully resorbable tubular stents, and polymer coatings. The polymer devices that differed in their shape and mass were introduced into muscles, bones, blood vessels, and internal organs in order to investigate the response of tissues with different structure to the implants. The studies showed that PHAs were highly biocompatible with different tissues and their implantation for extended periods of time did not induce adverse responses of the blood system, cells, tissues, or the entire organism. The authors proved that PHAs can be effectively used as prosthetic implants, suture material, bone-replacing implants, and matrices for drug delivery. © 2014 by Nova Science Publishers, Inc. All rights reserved.
Журнал: Polyhydroxyalkanoates (PHAs): Biosynthesis, Industrial Production and Applications in Medicine
Номера страниц: 273-330
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