New crystalline betulin-based materials: improving betulin solubility via cocrystal formation | Научно-инновационный портал СФУ

New crystalline betulin-based materials: improving betulin solubility via cocrystal formation

Тип публикации: доклад, тезисы доклада, статья из сборника материалов конференций

Конференция: International Conference on Fundamental Bases of Mechanochemical Technologies (FBMT); Russian Acad Sci, Serbian Branch, Inst Solid State Chem & Mechanochemistry, Novosibirsk, RUSSIA; Russian Acad Sci, Serbian Branch, Inst Solid State Chem & Mechanochemistry, Novosibirsk, RUSSIA

Год издания: 2019

Идентификатор DOI: 10.1016/j.matpr.2019.03.069

Ключевые слова: Betulin, dicarboxylic acids, co-grinding, cocrystals, solubility

Аннотация: The cocrystal formation potential of betulin with aliphatic dicarboxylic acids was investigated. Carboxylic acids of varying carbon chain length, namely: adipic, succinic and suberic acids, were selected to explore the effect of the coformer structure on The cocrystal formation potential of betulin with aliphatic dicarboxylic acids was investigated. Carboxylic acids of varying carbon chain length, namely: adipic, succinic and suberic acids, were selected to explore the effect of the coformer structure on cocrystal formation when liquid-assisted grinding was used. Cocrystal formation was characterized by powder XRD and IR studies. Betulin cocrystals with adipic acid were successfully synthesized and HPLC analysis showed that solubility of the betulin cocrystal was significantly improved compared to the initial betulin and its mechanocomposite with polymer. © 2019 Elsevier Ltd. All rights reserved.

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Издание

Журнал: MATERIALS TODAY-PROCEEDINGS

Выпуск журнала: Vol. 12, Part 1

Номера страниц: 82-85

ISSN журнала: 22147853

Место издания: AMSTERDAM

Издатель: ELSEVIER SCIENCE BV

Авторы

  • Myz Svetlana A. (RAS, Inst Solid State Chem & Mechanochem, SB, Kutateladze Str,18, Novosibirsk 630128, Russia; Novosibirsk State Univ, Pirogov Str,2, Novosibirsk 630090, Russia)
  • Mikhailovskaya Anastasiya V. (Novosibirsk State Univ, Pirogov Str,2, Novosibirsk 630090, Russia)
  • Mikhailenko Mikhail A. (RAS, Inst Solid State Chem & Mechanochem, SB, Kutateladze Str,18, Novosibirsk 630128, Russia)
  • Bulina Natalia V. (RAS, Inst Solid State Chem & Mechanochem, SB, Kutateladze Str,18, Novosibirsk 630128, Russia)
  • Kuznetsova Svetlana A. (RAS, Inst Chem & Chem Technol, SB, FRC,KSC, Academgorodok,50-24, Krasnoyarsk 660036, Russia; Siberian Fed Univ, Svobodny Pr,79-10, Krasnoyarsk 660041, Russia)
  • Shakhtshneider Tatyana P. (RAS, Inst Solid State Chem & Mechanochem, SB, Kutateladze Str,18, Novosibirsk 630128, Russia; Novosibirsk State Univ, Pirogov Str,2, Novosibirsk 630090, Russia)

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