Сибирский федеральный университет

Тип публикации: статья из журнала

Год издания: 2017

Идентификатор DOI: 10.1007/s10517-017-3741-y

Ключевые слова: GJA5, KCNN3, SCN5A, single-nucleotide polymorphism, sudden cardiac death

Аннотация: We studied association of single-nucleotide SCN5A (rs1805124), GJA5 (rs35594137), and KCNN3 (rs13376333) polymorphisms and sudden cardiac death. Humans died suddenly from cardiac causes (N=379) and unrelated sex- and age-matched control subjects were genotyped. No significant intergroup differences were found in the frequency of rs1805124 and rs13376333 genotypes and alleles. In women under 50 years, enhanced risk of sudden cardiac death was associated with rs35594137 GG genotype (OR=3.6; 95%CI=1.2-10.4; p=0.022), while in older women it was associated with rs35594137 AA genotype (OR=3.0; 95%CI=2.3-3.9; p=0.041). In women under 50 years, GA rs35594137 genotype was associated with a protective effect against sudden cardiac death (OR=0.3; 95%CI=0.1-0.8; p=0.036). Thus, GJA5 gene rs35594137 polymorphism is significantly associated with sudden cardiac death in the examined group. © 2017, Springer Science+Business Media, LLC.

Журнал: Bulletin of Experimental Biology and Medicine

Выпуск журнала: Vol. 163, Is. 1

Номера страниц: 73-77

ISSN журнала: 00074888

Издатель: Springer New York LLC

• Ivanova A.A. (Research Institute of Therapy and Preventive Medicine, Novosibirsk, Russian Federation)
• Maksimov V.N. (Research Institute of Therapy and Preventive Medicine, Novosibirsk, Russian Federation, Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russian Federation)
• Ivanoshchuk D.E. (Research Institute of Therapy and Preventive Medicine, Novosibirsk, Russian Federation, Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russian Federation, Novosibirsk National Research State University, Novosibirsk, Russian Federation)
• Orlov P.S. (Research Institute of Therapy and Preventive Medicine, Novosibirsk, Russian Federation, Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russian Federation, Novosibirsk National Research State University, Novosibirsk, Russian Federation)
• Novoselov V.P. (Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russian Federation, Novosibirsk Regional Clinical Bureau of Forensic Medicine, Novosibirsk, Russian Federation)
• Savchenko S.V. (Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russian Federation, Novosibirsk Regional Clinical Bureau of Forensic Medicine, Novosibirsk, Russian Federation)
• Voevoda M.I. (Research Institute of Therapy and Preventive Medicine, Novosibirsk, Russian Federation, Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russian Federation, Novosibirsk National Research State University, Novosibirsk, Russian Federation)

• Scopus