Сибирский федеральный университет

Тип публикации: статья из журнала

Год издания: 2017

Идентификатор DOI: 10.1007/s10517-017-3801-3

Ключевые слова: ascitic tumor, liposomes, metastases, platinum compoundsphosphatidylcholine, 55128-59-1, 8002-43-5

Аннотация: Antimetastatic activity of Platin in lyophilized liposomes stored for 7 years after fabrication was evaluated. The main flaw of liposomes as vehicles for drug delivery to the tumors is their high affinity for the liver, which accumulates a great amount thereof. This property of liposomes can be used for adjuvant therapy of operable primary tumors metastasizing to the liver. It is shown on the model of mouse GA-1 tumor metastases in the liver that platinum(II) complex compound Platin in phosphatidylcholine-cholesterol liposomes, stored for 7 years after lyophilization, causes complete cure of 40% animals, while free Platin prolongs the lifespan of mice with tumors by only 31.7% vs. control (no treatment). © 2017, Springer Science+Business Media, LLC.

Журнал: Bulletin of Experimental Biology and Medicine

Выпуск журнала: Vol. 163, Is. 3

Номера страниц: 349-351

ISSN журнала: 00074888

Издатель: Springer New York LLC

• Kaledin V.I. (Federal Research Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russian Federation)
• Nikolin V.P. (Federal Research Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russian Federation)
• Popova N.A. (Federal Research Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russian Federation, Novosibirsk National Research State University, Novosibirsk, Russian Federation)
• Klinnikova M.G. (Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russian Federation)
• Bogdanova L.A. (Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russian Federation)
• Morozkova T.S. (Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russian Federation)

• Scopus