Тип публикации: доклад, тезисы доклада, статья из сборника материалов конференций
Конференция: International Conference on Atomic and Molecular Pulsed Lasers; Tomsk, RUSSIA; Tomsk, RUSSIA
Год издания: 2018
Идентификатор DOI: 10.1117/12.2303545
Ключевые слова: Absorption, Excited-state dipole moment, Fluorescence, Naphtho[1,2,3-cd]indole-6(2n)-one, Polarity function, Quantum yield, Solute-solvent interaction, Solvatochromism
Аннотация: Recently synthesized pyrrolanthrone, naphtho[1,2,3-cd]indole-6(2H)-one (PyAn), and its water-soluble derivative, 3(naphtho[1,2,3-cd]indole-6(2H)-one-2-yl) sodium propylsulfonate, are very promising for anticancer therapy due to both the fluorescent and cytotoxic properties. The present study is focused on the spectroscopic analysis of solvent effects in PyAn and its derivative. An increase of the solvent polarity results in the bathochromic shift in emission and absorption spectra that indicates the involvement of ππ∗-type transition. The double linear correlation of Stokes shift with bulk solvent polarity functions (in terms of Lippert's, Bakhshiev's and Chamma-Viallet's models) and microscopic solvent polarity parameter () 30 N ET for aprotic and protic solvents is observed. Both general and specific solvent effects are revealed for the solute-solvent systems. Fluorescence quantum yield, fluorescence lifetime and excited-state dipole moment were defined for PyAn and its derivative in different solvents for the first time. The obtained information is of a great importance for the characterization of intermolecular interactions of drugs with biomolecules for the development of new drug delivery systems. © 2018 SPIE.
Издание
Журнал: Proceedings of SPIE - The International Society for Optical Engineering
Выпуск журнала: Vol. 10614
Номера страниц: 1061423
ISSN журнала: 0277786X
Издатель: SPIE
Персоны
- Merezhko A.G. (Siberian Fed Univ, 79 Svobodny Prospect, Krasnoyarsk 660041, Russia)
- Gerasimova M.A. (Siberian Fed Univ, 79 Svobodny Prospect, Krasnoyarsk 660041, Russia)
- Gornostaev L.M. (Astafev Krasnoyarsk State Pedag Univ, 89 A Lebedevoy Str, Krasnoyarsk 660049, Russia)
- Tropina D.A. (Astafev Krasnoyarsk State Pedag Univ, 89 A Lebedevoy Str, Krasnoyarsk 660049, Russia)
- Slyusareva E.A. (Siberian Fed Univ, 79 Svobodny Prospect, Krasnoyarsk 660041, Russia)
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