Тип публикации: статья из журнала
Год издания: 2013
Идентификатор DOI: 10.1007/s10600-013-0641-x
Ключевые слова: betulin diacetate, arabinogalactan, mechanochemical treatment, dissolution, gel-permeation chromatography, antitumor properties
Аннотация: It was shown using gel-permeation chromatography that arabinogalactan in a SPEX 8000 ball mill changed its molecular-weight distribution (MWD) after mechanochemical treatment. The presence of betulin diacetate assisted the reduction of the MWD after dissolution of the mechanically activated mixture in water and evaporation of the solvent. Complexes of betulin diacetate with arabinogalactan were also obtained as thin films that were readily soluble in water. Mechanical composites of arabinogalactan with betulin diacetate were capable of inducing cell elimination processes mediated by disruption of ionic homeostasis in Ehrlich ascites carcinoma cells.
Издание
Журнал: CHEMISTRY OF NATURAL COMPOUNDS
Выпуск журнала: Vol. 49, Is. 3
Номера страниц: 470-474
ISSN журнала: 00093130
Место издания: NEW YORK
Издатель: SPRINGER
Персоны
- Shakhtshneider T.P. (Scientific and Educational Center Molecular Design and Ecologically Safe Technologies,Novosibirsk State University)
- Mikhailenko M.A. (Scientific and Educational Center Molecular Design and Ecologically Safe Technologies,Novosibirsk State University)
- Boldyrev V.V. (Scientific and Educational Center Molecular Design and Ecologically Safe Technologies,Novosibirsk State University)
- Kuznetsova S.A. (Siberian Federal University)
- Zamai A.S. (V. F. Voino-Yasenetskii Krasnoyarsk State Medical University)
- Malyar Y.N. (Siberian Federal University)
- Zamai T.N. (V. F. Voino-Yasenetskii Krasnoyarsk State Medical University)
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