Effect of Mechanochemical Treatment on Physicochemical and Antitumor Properties of Betulin Diacetate Mixtures with Arabinogalactan | Научно-инновационный портал СФУ

Effect of Mechanochemical Treatment on Physicochemical and Antitumor Properties of Betulin Diacetate Mixtures with Arabinogalactan

Тип публикации: статья из журнала

Год издания: 2013

Идентификатор DOI: 10.1007/s10600-013-0641-x

Ключевые слова: betulin diacetate, arabinogalactan, mechanochemical treatment, dissolution, gel-permeation chromatography, antitumor properties

Аннотация: It was shown using gel-permeation chromatography that arabinogalactan in a SPEX 8000 ball mill changed its molecular-weight distribution (MWD) after mechanochemical treatment. The presence of betulin diacetate assisted the reduction of the MWD after dissolution of the mechanically activated mixture in water and evaporation of the solvent. Complexes of betulin diacetate with arabinogalactan were also obtained as thin films that were readily soluble in water. Mechanical composites of arabinogalactan with betulin diacetate were capable of inducing cell elimination processes mediated by disruption of ionic homeostasis in Ehrlich ascites carcinoma cells.

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Издание

Журнал: CHEMISTRY OF NATURAL COMPOUNDS

Выпуск журнала: Vol. 49, Is. 3

Номера страниц: 470-474

ISSN журнала: 00093130

Место издания: NEW YORK

Издатель: SPRINGER

Авторы

  • Shakhtshneider T.P. (Scientific and Educational Center Molecular Design and Ecologically Safe Technologies,Novosibirsk State University)
  • Mikhailenko M.A. (Scientific and Educational Center Molecular Design and Ecologically Safe Technologies,Novosibirsk State University)
  • Boldyrev V.V. (Scientific and Educational Center Molecular Design and Ecologically Safe Technologies,Novosibirsk State University)
  • Kuznetsova S.A. (Siberian Federal University)
  • Zamai A.S. (V. F. Voino-Yasenetskii Krasnoyarsk State Medical University)
  • Malyar Y.N. (Siberian Federal University)
  • Zamai T.N. (V. F. Voino-Yasenetskii Krasnoyarsk State Medical University)

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