Study of electrokinetic potential of drug micro-carriers prepared from resorbable polymers bioplastotan

Тип публикации: статья из журнала

Год издания: 2014

Идентификатор DOI: 10.1134/S000635091404023X

Ключевые слова: controlled drug delivery systems, electrokinetic potential, microparticles, poly-3-hydroxybutyrate, resorbable polymers

Аннотация: The study investigates electrokinetic potentials of microparticles prepared from biodegradable poly-3-hydroxybutyrate depending upon the method of preparation employed and taking into account the size of particles maintained in liquid media. The ?-potential of microparticles prepared from emulsion by solvent evaporation method was ?20 mV; the ?-potential of microparticles prepared by spray drying was reduced to ?95 mV. The value of ?-potential was influenced by drug loading into microparticles; the drug-loaded microparticles maintained in balanced phosphate buffer for 30 days had higher physical stability than those without drug loading. © 2014, Pleiades Publishing, Inc.

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Издание

Журнал: Biophysics (Russian Federation)

Выпуск журнала: Vol. 59, Is. 4

Номера страниц: 561-567

ISSN журнала: 00063509

Авторы

  • Shershneva A.M. (Siberian Federal University)
  • Shishatskaya E.I. (Institute of Biophysics, Siberian Branch, Russian Academy of Sciences)
  • Volova T.G. (Institute of Biophysics, Siberian Branch, Russian Academy of Sciences)
  • Murueva A.V. (Institute of Biophysics, Siberian Branch, Russian Academy of Sciences)

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